Morphologic revertants of murine sarcoma virus transformed nonproducer BALB/3T3: Selective techniques for isolation and biologic properties in vitro and in vivo

Joel S. Greenberger; Stuart A. Aaronson

doi:10.1016/0042-6822(74)90173-1

Morphologic revertants of murine sarcoma virus transformed nonproducer BALB/3T3: Selective techniques for isolation and biologic properties in vitro and in vivo

Joel S. Greenberger, Stuart A. Aaronson

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Revertant clones of murine sarcoma virus transformed nonproducer BALB/3T3 cells have been isolated by selection of iododeoxyuridine-resistant colonies in methylcellulose. Each revertant contained a rescuable sarcoma virus but demonstrated both in vitro and in vivo biologic properties of nontransformed BALB/3T3 cells. Further, each clone was highly susceptible to retransformation by added sarcoma virus. The evidence indicates that these lines comprise a new class of morphologic revertants of murine sarcoma virus transformed cells.

Original language	English
Pages (from-to)	339-346
Number of pages	8
Journal	Virology
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(74)90173-1
State	Published - Feb 1974
Externally published	Yes

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Morphologic revertants of murine sarcoma virus transformed nonproducer BALB/3T3: Selective techniques for isolation and biologic properties in vitro and in vivo

Abstract

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