Mood and cognition in leucine-rich repeat kinase 2 G2019S Parkinson's disease

Vicki Shanker, Mark Groves, Gary Heiman, Christina Palmese, Rachel Saunders-Pullman, Laurie Ozelius, Deborah Raymond, Susan Bressman

Research output: Contribution to journalLetterpeer-review

33 Scopus citations


The behavioral and cognitive features of the leucine-rich repeat kinase G2019S mutation in Parkinson's disease in the Ashkenazi Jewish population are not well described; therefore, we sought to more systematically characterize these features using a semistructured psychiatric interview and neuropsychological testing. Twenty-one Ashkenazi Jewish patients having the leucine-rich repeat kinase G2019S mutation were compared with age- and sex-matched Ashkenazi Jewish patients with Parkinson's disease without mutations. Although overall rates of affective disorders were not greater in mutation carriers, the carriers exhibited a 6-fold increased risk of premorbid affective disorders (odds ratio, 6.0; P = .10), as determined by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-IV. Of interest, we identified 2 leucine-rich repeat kinase carriers with bipolar disorder; no mutation-negative subjects had this diagnosis. Performance on the Hopkins Verbal Learning Test-Revised, Judgment of Line Orientation, and Frontal Assessment Battery was consistent with previous reports and did not differ between groups. Study findings suggest a possible association between premorbid mood disorders and leucine-rich repeat kinase Parkinson's disease, warranting further evaluation.

Original languageEnglish
Pages (from-to)1875-1880
Number of pages6
JournalMovement Disorders
Issue number10
StatePublished - 15 Aug 2011
Externally publishedYes


  • Cognition
  • Depression
  • Leucine-rich repeat kinase 2
  • Mood
  • Parkinson's disease


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