Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome

Keyphrases

• Autoimmunity 100%
• Early Onset 100%
• Natural History 100%
• Monogenic 100%
• Lymphoproliferation 100%
• Gain-of-function 100%
• Overall Survival 50%
• Germ Cells 50%
• Immune Thrombocytopenia 50%
• Gain-of-function Variant 50%
• Immunosuppressive Therapy 25%
• Age of Onset 25%
• Multisystem 25%
• Inclusion Criteria 25%
• Treatment Modalities 25%
• T Cells 25%
• Patient Care 25%
• Treatment Strategy 25%
• Clinical Manifestations 25%
• Gain-of-function mutation 25%
• Prompt Treatment 25%
• Pulmonary Disease 25%
• Clinical Symptoms 25%
• Renal Disease 25%
• Survival Rate 25%
• Age at Diagnosis 25%
• Immune-mediated Diseases 25%
• International Cohort 25%
• Bone Marrow Transplantation 25%
• Treatment Survival 25%
• Immune Dysregulation 25%
• Double Negative 25%
• Skin Diseases 25%
• Symptom Onset 25%
• Neurological Diseases 25%
• Lifesaving 25%
• Growth Delay 25%
• Autoimmune Hepatitis 25%
• Early Identification 25%
• Arthritis 25%
• Unique mutation 25%
• Vasculopathy 25%
• Multisystem Disease 25%
• Enteropathy 25%
• Signal Transducer and Activator of Transcription 3 25%
• Endocrinopathy 25%
• JAK Inhibitors 25%
• Treatment Implementation 25%
• Cellular Immunodeficiency 25%
• Renal Malignancy 25%
• Humoral Immunodeficiency 25%

Medicine and Dentistry

• Autoimmunity 100%
• Lymphocyte Proliferation 100%
• Overall Survival 50%
• Immunity 50%
• Cytopenia 50%
• Germ Cell 50%
• Nephropathy 25%
• Cancer 25%
• Onset Age 25%
• Infection 25%
• Patient Care 25%
• Dermatosis 25%
• Neurologic Disease 25%
• Vascular Disease 25%
• Immune Deficiency 25%
• Survival Rate 25%
• Cohort Analysis 25%
• Silo-Filler's Disease 25%
• T Cell 25%
• Bone Marrow Transplantation 25%
• Arthritis 25%
• Systemic Disease 25%
• Endocrine Disease 25%
• Autoimmune Hepatitis 25%
• Enteropathy 25%
• STAT3 Protein 25%
• Gain of Function Mutation 25%
• Immune Dysregulation 25%
• Janus Kinase Inhibitor 25%
• Diseases 25%

Immunology and Microbiology

• Autoimmunity 100%
• STAT3 100%
• Lymphocyte Proliferation 100%
• Overall Survival 33%
• Immunity 33%
• Germ Cell 33%
• T Cell 16%
• Immunodeficiency 16%
• Survival Rate 16%
• Immune Dysregulation 16%
• Autoimmune Hepatitis 16%
• Bone Marrow Transplantation 16%
• Arthritis 16%
• Gain of Function Mutation 16%