TY - JOUR
T1 - Monoclonal antibody therapy in sinonasal disease
AU - Chiarella, Sergio E.
AU - Sy, Hendrik
AU - Peters, Anju T.
N1 - Publisher Copyright:
© Copyright 2017, OceanSide Publications, Inc., U.S.A.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Chronic rhinosinusitis (CRS) affects 12.5% of the U.S. population. CRS can be divided into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps. Some individuals with CRSwNP do not respond to standard-of-care medical and surgical management. For these individuals, targeted biologic agents are emerging as an important therapeutic alternative. In this review, we described the most-relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-interleukin 5 (mepolizumab and reslizumab), and anti-interleukin 4/interleukin 13 (dupilumab) monoclonal antibodies for the treatment of CRSwNP. In addition, we discussed the importance of some of these clinical trials in identifying new CRS endotypes based on distinct inflammatory profiles.
AB - Chronic rhinosinusitis (CRS) affects 12.5% of the U.S. population. CRS can be divided into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps. Some individuals with CRSwNP do not respond to standard-of-care medical and surgical management. For these individuals, targeted biologic agents are emerging as an important therapeutic alternative. In this review, we described the most-relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-interleukin 5 (mepolizumab and reslizumab), and anti-interleukin 4/interleukin 13 (dupilumab) monoclonal antibodies for the treatment of CRSwNP. In addition, we discussed the importance of some of these clinical trials in identifying new CRS endotypes based on distinct inflammatory profiles.
UR - http://www.scopus.com/inward/record.url?scp=85015759888&partnerID=8YFLogxK
U2 - 10.2500/ajra.2017.31.4412
DO - 10.2500/ajra.2017.31.4412
M3 - Article
C2 - 28281440
AN - SCOPUS:85015759888
SN - 1945-8924
VL - 31
SP - 93
EP - 95
JO - American Journal of Rhinology and Allergy
JF - American Journal of Rhinology and Allergy
IS - 2
ER -