Monitoring Progressive Multiple Sclerosis with Novel Imaging Techniques

Maria Petracca, Monica Margoni, Giulia Bommarito, Matilde Inglese

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Imaging markers for monitoring disease progression in progressive multiple sclerosis (PMS) are scarce, thereby limiting the possibility to monitor disease evolution and to test effective treatments in clinical trials. Advanced imaging techniques that have the advantage of metrics with increased sensitivity to short-term tissue changes and increased specificity to the structural abnormalities characteristic of PMS have recently been applied in clinical trials of PMS. In this review, we (1) provide an overview of the pathological features of PMS, (2) summarize the findings of research and clinical trials conducted in PMS which have applied conventional and advanced magnetic resonance imaging techniques and (3) discuss recent advancements and future perspectives in monitoring PMS with imaging techniques.

Original languageEnglish
Pages (from-to)265-285
Number of pages21
JournalNeurology and Therapy
Issue number2
StatePublished - 1 Dec 2018


  • Advanced imaging
  • Biomarker
  • Clinical trials
  • Progressive multiple sclerosis


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