Monitoring medication adherence in multiple sclerosis using a novel web-based tool: A pilot study

Jill R. Settle, Heidi W. Maloni, McKenzie Bedra, Joseph Finkelstein, Min Zhan, Mitchell T. Wallin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Monitoring medication adherence in multiple sclerosis (MS) can be time consuming and expensive; however, non-adherence is common and is very costly in terms of lost therapeutic benefit and unused medications. To address this problem, we employed a web-based system to monitor and potentially modify medication adherence. Participants (n = 30) were randomized either to routine care or to the MS Home Automated Telehealth (MS HAT) system. Weekly interferon beta-1a intramuscular (INFbeta-1a IM) injections and daily vitamin D adherence were tracked over a six-month period using multiple modalities: self-reported adherence, calendar diaries, pharmacy refill rates, blood serum levels, and MS HAT alerts. Weekly INFbeta-1a IM adherence was highly correlated across measures; however, vitamin D adherence was not as consistent. Healthcare providers were able to efficiently monitor adherence in a patient-centered way by using the MS HAT system to monitor adherence rather than employing chart reviews and phone calls. In addition, patients with more preserved cognitive function appeared to benefit more from use of the MS HAT system than those with cognitive impairment. While further research is needed to understand the differential effects of MS HAT on specific medications and for different individuals, it is a promising tool for monitoring medication adherence in patients with MS.

Original languageEnglish
Pages (from-to)225-233
Number of pages9
JournalJournal of Telemedicine and Telecare
Issue number4
StatePublished - Jun 2016
Externally publishedYes


  • Multiple sclerosis
  • medication adherence
  • monitoring
  • telehealth


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