Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T

Wafaa Zaaraoui; Mathilde Deloire; Michel Merle; Céline Girard; Gérard Raffard; Marc Biran; Matilde Inglese; Klaus G. Petry; Oded Gonen; Bruno Brochet; Jean Michel Franconi; Vincent Dousset

doi:10.1007/s10334-008-0141-3

Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T

Wafaa Zaaraoui, Mathilde Deloire, Michel Merle, Céline Girard, Gérard Raffard, Marc Biran, Matilde Inglese, Klaus G. Petry, Oded Gonen, Bruno Brochet, Jean Michel Franconi, Vincent Dousset

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Objective: The aim of this study was to assess quantitatively structural changes in myelin content occurring during demyelination and remyelination by magnetization transfer imaging (MTI). Materials and methods: In a reversible model of demyelination with no axonal loss, mice intoxicated by cuprizone were studied by MTI in vivo at 9.4 T. MRI data were compared to histopathological examinations. Results: Data revealed that the magnetization transfer ratio (MTR) decreased significantly during demyelination and increased during remyelination with strong correlation to the myelin content (r = 0.79, P = 0.01). Conclusions: This study demonstrated that MTR is a sensitive and reproducible quantitative marker to assess myelin loss and repair. This may lead to in vivo monitoring of therapeutic strategies promoting remyelination.

Original language	English
Pages (from-to)	357-362
Number of pages	6
Journal	Magnetic Resonance Materials in Physics, Biology and Medicine
Volume	21
Issue number	5
DOIs	https://doi.org/10.1007/s10334-008-0141-3
State	Published - Sep 2008
Externally published	Yes

Keywords

Cuprizone
Demyelination
Histology
Magnetization transfer imaging
Magnetization transfer ratio
Remyelination

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10.1007/s10334-008-0141-3

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Zaaraoui, W., Deloire, M., Merle, M., Girard, C., Raffard, G., Biran, M., Inglese, M., Petry, K. G., Gonen, O., Brochet, B., Franconi, J. M., & Dousset, V. (2008). Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T. Magnetic Resonance Materials in Physics, Biology and Medicine, 21(5), 357-362. https://doi.org/10.1007/s10334-008-0141-3

@article{b1e35c1e8c2f4861a76eac693082e081,

title = "Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T",

abstract = "Objective: The aim of this study was to assess quantitatively structural changes in myelin content occurring during demyelination and remyelination by magnetization transfer imaging (MTI). Materials and methods: In a reversible model of demyelination with no axonal loss, mice intoxicated by cuprizone were studied by MTI in vivo at 9.4 T. MRI data were compared to histopathological examinations. Results: Data revealed that the magnetization transfer ratio (MTR) decreased significantly during demyelination and increased during remyelination with strong correlation to the myelin content (r = 0.79, P = 0.01). Conclusions: This study demonstrated that MTR is a sensitive and reproducible quantitative marker to assess myelin loss and repair. This may lead to in vivo monitoring of therapeutic strategies promoting remyelination.",

keywords = "Cuprizone, Demyelination, Histology, Magnetization transfer imaging, Magnetization transfer ratio, Remyelination",

author = "Wafaa Zaaraoui and Mathilde Deloire and Michel Merle and C{\'e}line Girard and G{\'e}rard Raffard and Marc Biran and Matilde Inglese and Petry, {Klaus G.} and Oded Gonen and Bruno Brochet and Franconi, {Jean Michel} and Vincent Dousset",

note = "Funding Information: Acknowledgments This study was supported by ARSEP, ARMA, CNRS, programme Imagerie du Petit Animal and R{\'e}gion Aquitaine.",

year = "2008",

month = sep,

doi = "10.1007/s10334-008-0141-3",

language = "English",

volume = "21",

pages = "357--362",

journal = "Magnetic Resonance Materials in Physics, Biology and Medicine",

issn = "0968-5243",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "5",

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Zaaraoui, W, Deloire, M, Merle, M, Girard, C, Raffard, G, Biran, M, Inglese, M, Petry, KG, Gonen, O, Brochet, B, Franconi, JM & Dousset, V 2008, 'Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T', Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 21, no. 5, pp. 357-362. https://doi.org/10.1007/s10334-008-0141-3

TY - JOUR

T1 - Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T

AU - Zaaraoui, Wafaa

AU - Deloire, Mathilde

AU - Merle, Michel

AU - Girard, Céline

AU - Raffard, Gérard

AU - Biran, Marc

AU - Inglese, Matilde

AU - Petry, Klaus G.

AU - Gonen, Oded

AU - Brochet, Bruno

AU - Franconi, Jean Michel

AU - Dousset, Vincent

N1 - Funding Information: Acknowledgments This study was supported by ARSEP, ARMA, CNRS, programme Imagerie du Petit Animal and Région Aquitaine.

PY - 2008/9

Y1 - 2008/9

N2 - Objective: The aim of this study was to assess quantitatively structural changes in myelin content occurring during demyelination and remyelination by magnetization transfer imaging (MTI). Materials and methods: In a reversible model of demyelination with no axonal loss, mice intoxicated by cuprizone were studied by MTI in vivo at 9.4 T. MRI data were compared to histopathological examinations. Results: Data revealed that the magnetization transfer ratio (MTR) decreased significantly during demyelination and increased during remyelination with strong correlation to the myelin content (r = 0.79, P = 0.01). Conclusions: This study demonstrated that MTR is a sensitive and reproducible quantitative marker to assess myelin loss and repair. This may lead to in vivo monitoring of therapeutic strategies promoting remyelination.

AB - Objective: The aim of this study was to assess quantitatively structural changes in myelin content occurring during demyelination and remyelination by magnetization transfer imaging (MTI). Materials and methods: In a reversible model of demyelination with no axonal loss, mice intoxicated by cuprizone were studied by MTI in vivo at 9.4 T. MRI data were compared to histopathological examinations. Results: Data revealed that the magnetization transfer ratio (MTR) decreased significantly during demyelination and increased during remyelination with strong correlation to the myelin content (r = 0.79, P = 0.01). Conclusions: This study demonstrated that MTR is a sensitive and reproducible quantitative marker to assess myelin loss and repair. This may lead to in vivo monitoring of therapeutic strategies promoting remyelination.

KW - Cuprizone

KW - Demyelination

KW - Histology

KW - Magnetization transfer imaging

KW - Magnetization transfer ratio

KW - Remyelination

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U2 - 10.1007/s10334-008-0141-3

DO - 10.1007/s10334-008-0141-3

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C2 - 18779984

AN - SCOPUS:51849145428

SN - 0968-5243

VL - 21

SP - 357

EP - 362

JO - Magnetic Resonance Materials in Physics, Biology and Medicine

JF - Magnetic Resonance Materials in Physics, Biology and Medicine

IS - 5

ER -

Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T

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Keywords

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