Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T

Wafaa Zaaraoui, Mathilde Deloire, Michel Merle, Céline Girard, Gérard Raffard, Marc Biran, Matilde Inglese, Klaus G. Petry, Oded Gonen, Bruno Brochet, Jean Michel Franconi, Vincent Dousset

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Objective: The aim of this study was to assess quantitatively structural changes in myelin content occurring during demyelination and remyelination by magnetization transfer imaging (MTI). Materials and methods: In a reversible model of demyelination with no axonal loss, mice intoxicated by cuprizone were studied by MTI in vivo at 9.4 T. MRI data were compared to histopathological examinations. Results: Data revealed that the magnetization transfer ratio (MTR) decreased significantly during demyelination and increased during remyelination with strong correlation to the myelin content (r = 0.79, P = 0.01). Conclusions: This study demonstrated that MTR is a sensitive and reproducible quantitative marker to assess myelin loss and repair. This may lead to in vivo monitoring of therapeutic strategies promoting remyelination.

Original languageEnglish
Pages (from-to)357-362
Number of pages6
JournalMagnetic Resonance Materials in Physics, Biology, and Medicine
Volume21
Issue number5
DOIs
StatePublished - Sep 2008
Externally publishedYes

Keywords

  • Cuprizone
  • Demyelination
  • Histology
  • Magnetization transfer imaging
  • Magnetization transfer ratio
  • Remyelination

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