TY - JOUR
T1 - Molecules, mechanisms, and disorders of self-domestication
T2 - Keys for understanding emotional and social communication from an evolutionary perspective
AU - Šimić, Goran
AU - Vukić, Vana
AU - Kopić, Janja
AU - Krsnik, Željka
AU - Hof, Patrick R.
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/1
Y1 - 2021/1
N2 - The neural crest hypothesis states that the phenotypic features of the domestication syndrome are due to a reduced number or disruption of neural crest cells (NCCs) migration, as these cells differentiate at their final destinations and proliferate into different tissues whose activity is reduced by domestication. Comparing the phenotypic characteristics of modern and prehistoric man, it is clear that during their recent evolutionary past, humans also went through a process of self-domestication with a simultaneous prolongation of the period of socialization. This has led to the development of social abilities and skills, especially language, as well as neoteny. Disorders of neural crest cell development and migration lead to many different conditions such as Waardenburg syndrome, Hirschsprung disease, fetal alcohol syndrome, DiGeorge and Treacher-Collins syndrome, for which the mechanisms are already relatively well-known. However, for others, such as WilliamsBeuren syndrome and schizophrenia that have the characteristics of hyperdomestication, and autism spectrum disorders, and 7dupASD syndrome that have the characteristics of hypodomestication, much less is known. Thus, deciphering the biological determinants of disordered self-domestication has great potential for elucidating the normal and disturbed ontogenesis of humans, as well as for the understanding of evolution of mammals in general.
AB - The neural crest hypothesis states that the phenotypic features of the domestication syndrome are due to a reduced number or disruption of neural crest cells (NCCs) migration, as these cells differentiate at their final destinations and proliferate into different tissues whose activity is reduced by domestication. Comparing the phenotypic characteristics of modern and prehistoric man, it is clear that during their recent evolutionary past, humans also went through a process of self-domestication with a simultaneous prolongation of the period of socialization. This has led to the development of social abilities and skills, especially language, as well as neoteny. Disorders of neural crest cell development and migration lead to many different conditions such as Waardenburg syndrome, Hirschsprung disease, fetal alcohol syndrome, DiGeorge and Treacher-Collins syndrome, for which the mechanisms are already relatively well-known. However, for others, such as WilliamsBeuren syndrome and schizophrenia that have the characteristics of hyperdomestication, and autism spectrum disorders, and 7dupASD syndrome that have the characteristics of hypodomestication, much less is known. Thus, deciphering the biological determinants of disordered self-domestication has great potential for elucidating the normal and disturbed ontogenesis of humans, as well as for the understanding of evolution of mammals in general.
KW - Chemoattractants
KW - Chemorepellents
KW - Epithelial-mesenchymal transition (EMT)
KW - Extracellular matrix molecules
KW - Fibroblast growth factor (FGF)
KW - Methyl-CpG-binding protein 2 (MeCP2)
KW - Neural crest cells (NCCs)
KW - Self-domestication
KW - Thyroid hormones
KW - Vascular endothelial growth factor (VEGF)
UR - http://www.scopus.com/inward/record.url?scp=85098775717&partnerID=8YFLogxK
U2 - 10.3390/biom11010002
DO - 10.3390/biom11010002
M3 - Review article
C2 - 33375093
AN - SCOPUS:85098775717
SN - 2218-273X
VL - 11
SP - 1
EP - 39
JO - Biomolecules
JF - Biomolecules
IS - 1
M1 - 2
ER -