Molecular targets of psychedelic-induced plasticity

Alaina M. Jaster, Mario de la Fuente Revenga, Javier González-Maeso

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic interest. Considering the central role of the serotonin 5-HT2A receptor in the distinct effects of psychedelics in human psyche, neuropharmacology sits at the center of this debate and exploratory continuum. Here we discuss some of the most recent findings in human studies and contextualize them considering previous preclinical models studying phenomena related to synaptic plasticity. A special emphasis is placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings of psychedelics’ potential antidepressant action. (Figure presented.).

Original languageEnglish
Pages (from-to)80-88
Number of pages9
JournalJournal of Neurochemistry
Volume162
Issue number1
DOIs
StatePublished - Jul 2022
Externally publishedYes

Keywords

  • 5-HT2A receptor
  • GPCR
  • LSD
  • hallucinogens
  • psychedelics
  • serotonin

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