Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers

PTSD Systems Biology Consortium

doi:10.1016/j.xcrm.2023.101045

Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers

PTSD Systems Biology Consortium

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Post-traumatic stress disorder (PTSD) is a multisystem syndrome. Integration of systems-level multi-modal datasets can provide a molecular understanding of PTSD. Proteomic, metabolomic, and epigenomic assays are conducted on blood samples of two cohorts of well-characterized PTSD cases and controls: 340 veterans and 180 active-duty soldiers. All participants had been deployed to Iraq and/or Afghanistan and exposed to military-service-related criterion A trauma. Molecular signatures are identified from a discovery cohort of 218 veterans (109/109 PTSD+/−). Identified molecular signatures are tested in 122 separate veterans (62/60 PTSD+/−) and in 180 active-duty soldiers (PTSD+/−). Molecular profiles are computationally integrated with upstream regulators (genetic/methylation/microRNAs) and functional units (mRNAs/proteins/metabolites). Reproducible molecular features of PTSD are identified, including activated inflammation, oxidative stress, metabolic dysregulation, and impaired angiogenesis. These processes may play a role in psychiatric and physical comorbidities, including impaired repair/wound healing mechanisms and cardiovascular, metabolic, and psychiatric diseases.

Original language	English
Article number	101045
Journal	Cell Reports Medicine
Volume	4
Issue number	5
DOIs	https://doi.org/10.1016/j.xcrm.2023.101045
State	Published - 16 May 2023

Keywords

active duty
angiogenesis
inflammatory response
metabolic dysregulation
molecular signature
multi-omics
oxidative stress
post-traumatic stress disorder
veterans
wound healing

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10.1016/j.xcrm.2023.101045

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title = "Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers",

abstract = "Post-traumatic stress disorder (PTSD) is a multisystem syndrome. Integration of systems-level multi-modal datasets can provide a molecular understanding of PTSD. Proteomic, metabolomic, and epigenomic assays are conducted on blood samples of two cohorts of well-characterized PTSD cases and controls: 340 veterans and 180 active-duty soldiers. All participants had been deployed to Iraq and/or Afghanistan and exposed to military-service-related criterion A trauma. Molecular signatures are identified from a discovery cohort of 218 veterans (109/109 PTSD+/−). Identified molecular signatures are tested in 122 separate veterans (62/60 PTSD+/−) and in 180 active-duty soldiers (PTSD+/−). Molecular profiles are computationally integrated with upstream regulators (genetic/methylation/microRNAs) and functional units (mRNAs/proteins/metabolites). Reproducible molecular features of PTSD are identified, including activated inflammation, oxidative stress, metabolic dysregulation, and impaired angiogenesis. These processes may play a role in psychiatric and physical comorbidities, including impaired repair/wound healing mechanisms and cardiovascular, metabolic, and psychiatric diseases.",

keywords = "active duty, angiogenesis, inflammatory response, metabolic dysregulation, molecular signature, multi-omics, oxidative stress, post-traumatic stress disorder, veterans, wound healing",

author = "{PTSD Systems Biology Consortium} and Seid Muhie and Aarti Gautam and Ruoting Yang and Burook Misganaw and Daigle, {Bernie J.} and Mellon, {Synthia H.} and Flory, {Janine D.} and Duna Abu-Amara and Inyoul Lee and Kai Wang and Ryan Rampersaud and Leroy Hood and Rachel Yehuda and Marmar, {Charles R.} and Wolkowitz, {Owen M.} and Ressler, {Kerry J.} and Doyle, {Francis J.} and Rasha Hammamieh and Marti Jett",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = may,

day = "16",

doi = "10.1016/j.xcrm.2023.101045",

language = "English",

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T1 - Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers

AU - PTSD Systems Biology Consortium

AU - Muhie, Seid

AU - Gautam, Aarti

AU - Yang, Ruoting

AU - Misganaw, Burook

AU - Daigle, Bernie J.

AU - Mellon, Synthia H.

AU - Flory, Janine D.

AU - Abu-Amara, Duna

AU - Lee, Inyoul

AU - Wang, Kai

AU - Rampersaud, Ryan

AU - Hood, Leroy

AU - Yehuda, Rachel

AU - Marmar, Charles R.

AU - Wolkowitz, Owen M.

AU - Ressler, Kerry J.

AU - Doyle, Francis J.

AU - Hammamieh, Rasha

AU - Jett, Marti

PY - 2023/5/16

Y1 - 2023/5/16

N2 - Post-traumatic stress disorder (PTSD) is a multisystem syndrome. Integration of systems-level multi-modal datasets can provide a molecular understanding of PTSD. Proteomic, metabolomic, and epigenomic assays are conducted on blood samples of two cohorts of well-characterized PTSD cases and controls: 340 veterans and 180 active-duty soldiers. All participants had been deployed to Iraq and/or Afghanistan and exposed to military-service-related criterion A trauma. Molecular signatures are identified from a discovery cohort of 218 veterans (109/109 PTSD+/−). Identified molecular signatures are tested in 122 separate veterans (62/60 PTSD+/−) and in 180 active-duty soldiers (PTSD+/−). Molecular profiles are computationally integrated with upstream regulators (genetic/methylation/microRNAs) and functional units (mRNAs/proteins/metabolites). Reproducible molecular features of PTSD are identified, including activated inflammation, oxidative stress, metabolic dysregulation, and impaired angiogenesis. These processes may play a role in psychiatric and physical comorbidities, including impaired repair/wound healing mechanisms and cardiovascular, metabolic, and psychiatric diseases.

AB - Post-traumatic stress disorder (PTSD) is a multisystem syndrome. Integration of systems-level multi-modal datasets can provide a molecular understanding of PTSD. Proteomic, metabolomic, and epigenomic assays are conducted on blood samples of two cohorts of well-characterized PTSD cases and controls: 340 veterans and 180 active-duty soldiers. All participants had been deployed to Iraq and/or Afghanistan and exposed to military-service-related criterion A trauma. Molecular signatures are identified from a discovery cohort of 218 veterans (109/109 PTSD+/−). Identified molecular signatures are tested in 122 separate veterans (62/60 PTSD+/−) and in 180 active-duty soldiers (PTSD+/−). Molecular profiles are computationally integrated with upstream regulators (genetic/methylation/microRNAs) and functional units (mRNAs/proteins/metabolites). Reproducible molecular features of PTSD are identified, including activated inflammation, oxidative stress, metabolic dysregulation, and impaired angiogenesis. These processes may play a role in psychiatric and physical comorbidities, including impaired repair/wound healing mechanisms and cardiovascular, metabolic, and psychiatric diseases.

KW - active duty

KW - angiogenesis

KW - inflammatory response

KW - metabolic dysregulation

KW - molecular signature

KW - multi-omics

KW - oxidative stress

KW - post-traumatic stress disorder

KW - veterans

KW - wound healing

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JO - Cell Reports Medicine

JF - Cell Reports Medicine

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ER -

Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers

Abstract

Keywords

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