Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy

Adrienne M. Luoma; Shengbao Suo; Hannah L. Williams; Tatyana Sharova; Keri Sullivan; Michael Manos; Peter Bowling; F. Stephen Hodi; Osama Rahma; Ryan J. Sullivan; Genevieve M. Boland; Jonathan A. Nowak; Stephanie K. Dougan; Michael Dougan; Guo Cheng Yuan; Kai W. Wucherpfennig

doi:10.1016/j.cell.2020.06.001

Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy

Adrienne M. Luoma
, Shengbao Suo
, Hannah L. Williams
, Tatyana Sharova
, Keri Sullivan
, Michael Manos
, Peter Bowling
, F. Stephen Hodi
, Osama Rahma
, Ryan J. Sullivan
, Genevieve M. Boland
, Jonathan A. Nowak
, Stephanie K. Dougan
, Michael Dougan
, Guo Cheng Yuan
, Kai W. Wucherpfennig

Research output: Contribution to journal › Article › peer-review

412 Scopus citations

Abstract

Single-cell analyses of immune checkpoint blockade-associated colitis patient samples reveal enrichment of regulatory T cells in colitic lesions and nominate inflammatory pathways for potential therapeutic intervention.

Original language	English
Pages (from-to)	655-671.e22
Journal	Cell
Volume	182
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2020.06.001
State	Published - 6 Aug 2020
Externally published	Yes

Keywords

CTLA-4
IFNγ
PD-1
TNFα
Trm
cancer
checkpoint blockade
cytotoxic T cells
immune-related adverse events
inflammatory cytokines
irAEs
tissue-resident memory T cells

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10.1016/j.cell.2020.06.001

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Luoma, A. M., Suo, S., Williams, H. L., Sharova, T., Sullivan, K., Manos, M., Bowling, P., Hodi, F. S., Rahma, O., Sullivan, R. J., Boland, G. M., Nowak, J. A., Dougan, S. K., Dougan, M., Yuan, G. C., & Wucherpfennig, K. W. (2020). Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy. Cell, 182(3), 655-671.e22. https://doi.org/10.1016/j.cell.2020.06.001

@article{4767a2755b3f46c8a75a22c5ea34d70a,

title = "Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy",

abstract = "Single-cell analyses of immune checkpoint blockade-associated colitis patient samples reveal enrichment of regulatory T cells in colitic lesions and nominate inflammatory pathways for potential therapeutic intervention.",

keywords = "CTLA-4, IFNγ, PD-1, TNFα, Trm, cancer, checkpoint blockade, cytotoxic T cells, immune-related adverse events, inflammatory cytokines, irAEs, tissue-resident memory T cells",

author = "Luoma, \{Adrienne M.\} and Shengbao Suo and Williams, \{Hannah L.\} and Tatyana Sharova and Keri Sullivan and Michael Manos and Peter Bowling and Hodi, \{F. Stephen\} and Osama Rahma and Sullivan, \{Ryan J.\} and Boland, \{Genevieve M.\} and Nowak, \{Jonathan A.\} and Dougan, \{Stephanie K.\} and Michael Dougan and Yuan, \{Guo Cheng\} and Wucherpfennig, \{Kai W.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = aug,

day = "6",

doi = "10.1016/j.cell.2020.06.001",

language = "English",

volume = "182",

pages = "655--671.e22",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy

AU - Luoma, Adrienne M.

AU - Suo, Shengbao

AU - Williams, Hannah L.

AU - Sharova, Tatyana

AU - Sullivan, Keri

AU - Manos, Michael

AU - Bowling, Peter

AU - Hodi, F. Stephen

AU - Rahma, Osama

AU - Sullivan, Ryan J.

AU - Boland, Genevieve M.

AU - Nowak, Jonathan A.

AU - Dougan, Stephanie K.

AU - Dougan, Michael

AU - Yuan, Guo Cheng

AU - Wucherpfennig, Kai W.

PY - 2020/8/6

Y1 - 2020/8/6

N2 - Single-cell analyses of immune checkpoint blockade-associated colitis patient samples reveal enrichment of regulatory T cells in colitic lesions and nominate inflammatory pathways for potential therapeutic intervention.

AB - Single-cell analyses of immune checkpoint blockade-associated colitis patient samples reveal enrichment of regulatory T cells in colitic lesions and nominate inflammatory pathways for potential therapeutic intervention.

KW - CTLA-4

KW - IFNγ

KW - PD-1

KW - TNFα

KW - Trm

KW - cancer

KW - checkpoint blockade

KW - cytotoxic T cells

KW - immune-related adverse events

KW - inflammatory cytokines

KW - irAEs

KW - tissue-resident memory T cells

UR - https://www.scopus.com/pages/publications/85087986491

U2 - 10.1016/j.cell.2020.06.001

DO - 10.1016/j.cell.2020.06.001

M3 - Article

C2 - 32603654

AN - SCOPUS:85087986491

SN - 0092-8674

VL - 182

SP - 655-671.e22

JO - Cell

JF - Cell

IS - 3

ER -

Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy

Abstract

Keywords

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