Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy

Adrienne M. Luoma, Shengbao Suo, Hannah L. Williams, Tatyana Sharova, Keri Sullivan, Michael Manos, Peter Bowling, F. Stephen Hodi, Osama Rahma, Ryan J. Sullivan, Genevieve M. Boland, Jonathan A. Nowak, Stephanie K. Dougan, Michael Dougan, Guo Cheng Yuan, Kai W. Wucherpfennig

Research output: Contribution to journalArticlepeer-review

179 Scopus citations


Single-cell analyses of immune checkpoint blockade-associated colitis patient samples reveal enrichment of regulatory T cells in colitic lesions and nominate inflammatory pathways for potential therapeutic intervention.

Original languageEnglish
Pages (from-to)655-671.e22
Issue number3
StatePublished - 6 Aug 2020
Externally publishedYes


  • CTLA-4
  • IFNγ
  • PD-1
  • TNFα
  • Trm
  • cancer
  • checkpoint blockade
  • cytotoxic T cells
  • immune-related adverse events
  • inflammatory cytokines
  • irAEs
  • tissue-resident memory T cells


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