Molecular pathology of non-invasive urothelial carcinomas (Part I)

Burkhard Helpap; Bernd J. Schmitz-Dräger; Peter W. Hamilton; Giovanni Muzzonigro; Andrea B. Galosi; Karl H. Kurth; David Lubaroff; David J. Waters; Michael J. Droller

doi:10.1007/s00428-002-0748-0

Molecular pathology of non-invasive urothelial carcinomas (Part I)

Burkhard Helpap
, Bernd J. Schmitz-Dräger
, Peter W. Hamilton
, Giovanni Muzzonigro
, Andrea B. Galosi
, Karl H. Kurth
, David Lubaroff
, David J. Waters
, Michael J. Droller

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

An international consultation on the diagnosis of non-invasive urothelial neoplasms was held in Ancona, Italy in May 2001. Besides histology and problems of classification, one group of experts (Committee no. 3) discussed the molecular pathology and cytometry of non-invasive urothelial carcinomas. In the following first part, special immunohistochemical and molecular markers for stratifications in bladder cancer were discussed including different cytokeratins (clone 34βE12, CK 20), cell proliferation markers (Ki67/MIB-1, PCNA, AgNOR, DNA-cytometry), tumor suppressor genes and oncogenes (p53, p21, erb-B2, bcl-2), different receptor expressions of epidermal growth factor and vascular endothelial growth factor and others. These molecular markers were analyzed in diagnosis of urothelial carcinomas, recurrences, progression and response to treatment.

Original language	English
Pages (from-to)	309-316
Number of pages	8
Journal	Virchows Archiv
Volume	442
Issue number	4
DOIs	https://doi.org/10.1007/s00428-002-0748-0
State	Published - 1 Apr 2003

Keywords

Cell proliferation
Cytokeratins
Non-invasive
Papillary bladder cancer
Tumor suppressor genes

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10.1007/s00428-002-0748-0

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title = "Molecular pathology of non-invasive urothelial carcinomas (Part I)",

abstract = "An international consultation on the diagnosis of non-invasive urothelial neoplasms was held in Ancona, Italy in May 2001. Besides histology and problems of classification, one group of experts (Committee no. 3) discussed the molecular pathology and cytometry of non-invasive urothelial carcinomas. In the following first part, special immunohistochemical and molecular markers for stratifications in bladder cancer were discussed including different cytokeratins (clone 34βE12, CK 20), cell proliferation markers (Ki67/MIB-1, PCNA, AgNOR, DNA-cytometry), tumor suppressor genes and oncogenes (p53, p21, erb-B2, bcl-2), different receptor expressions of epidermal growth factor and vascular endothelial growth factor and others. These molecular markers were analyzed in diagnosis of urothelial carcinomas, recurrences, progression and response to treatment.",

keywords = "Cell proliferation, Cytokeratins, Non-invasive, Papillary bladder cancer, Tumor suppressor genes",

author = "Burkhard Helpap and Schmitz-Dr{\"a}ger, \{Bernd J.\} and Hamilton, \{Peter W.\} and Giovanni Muzzonigro and Galosi, \{Andrea B.\} and Kurth, \{Karl H.\} and David Lubaroff and Waters, \{David J.\} and Droller, \{Michael J.\}",

year = "2003",

month = apr,

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doi = "10.1007/s00428-002-0748-0",

language = "English",

volume = "442",

pages = "309--316",

journal = "Virchows Archiv",

issn = "0945-6317",

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T1 - Molecular pathology of non-invasive urothelial carcinomas (Part I)

AU - Helpap, Burkhard

AU - Schmitz-Dräger, Bernd J.

AU - Hamilton, Peter W.

AU - Muzzonigro, Giovanni

AU - Galosi, Andrea B.

AU - Kurth, Karl H.

AU - Lubaroff, David

AU - Waters, David J.

AU - Droller, Michael J.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - An international consultation on the diagnosis of non-invasive urothelial neoplasms was held in Ancona, Italy in May 2001. Besides histology and problems of classification, one group of experts (Committee no. 3) discussed the molecular pathology and cytometry of non-invasive urothelial carcinomas. In the following first part, special immunohistochemical and molecular markers for stratifications in bladder cancer were discussed including different cytokeratins (clone 34βE12, CK 20), cell proliferation markers (Ki67/MIB-1, PCNA, AgNOR, DNA-cytometry), tumor suppressor genes and oncogenes (p53, p21, erb-B2, bcl-2), different receptor expressions of epidermal growth factor and vascular endothelial growth factor and others. These molecular markers were analyzed in diagnosis of urothelial carcinomas, recurrences, progression and response to treatment.

AB - An international consultation on the diagnosis of non-invasive urothelial neoplasms was held in Ancona, Italy in May 2001. Besides histology and problems of classification, one group of experts (Committee no. 3) discussed the molecular pathology and cytometry of non-invasive urothelial carcinomas. In the following first part, special immunohistochemical and molecular markers for stratifications in bladder cancer were discussed including different cytokeratins (clone 34βE12, CK 20), cell proliferation markers (Ki67/MIB-1, PCNA, AgNOR, DNA-cytometry), tumor suppressor genes and oncogenes (p53, p21, erb-B2, bcl-2), different receptor expressions of epidermal growth factor and vascular endothelial growth factor and others. These molecular markers were analyzed in diagnosis of urothelial carcinomas, recurrences, progression and response to treatment.

KW - Cell proliferation

KW - Cytokeratins

KW - Non-invasive

KW - Papillary bladder cancer

KW - Tumor suppressor genes

UR - https://www.scopus.com/pages/publications/0037688110

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DO - 10.1007/s00428-002-0748-0

M3 - Review article

C2 - 12715166

AN - SCOPUS:0037688110

SN - 0945-6317

VL - 442

SP - 309

EP - 316

JO - Virchows Archiv

JF - Virchows Archiv

IS - 4

ER -

Molecular pathology of non-invasive urothelial carcinomas (Part I)

Abstract

Keywords

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