@article{923e111a6bee40a28306f651c40fa0d9,
title = "Molecular pathogenesis of T-cell leukaemia and lymphoma",
abstract = "T-cell acute lymphoblastic leukaemia (T-ALL) is induced by the transformation of T-cell progenitors and mainly occurs in children and adolescents. Although treatment outcome in patients with T-ALL has improved in recent years, patients with relapsed disease continue to have a poor prognosis. It is therefore important to understand the molecular pathways that control both the induction of transformation and the treatment of relapsed disease. In this Review, we focus on the molecular mechanisms responsible for disease induction and maintenance. We also compare the physiological progression of T-cell differentiation with T-cell transformation, highlighting the close relationship between these two processes. Finally, we discuss potential new therapies that target oncogenic pathways in T-ALL.",
author = "Iannis Aifantis and Elizabeth Raetz and Silvia Buonamici",
note = "Funding Information: We thank W. Carroll, B. Mar and the members of the Aifantis laboratory for stimulating discussions and help with the preparation of the manuscript. Our work has been supported by the US National Institutes of Health (RO1CA105129), the American Cancer Society (RSG0806801), the Edward Mallinckrodt, Jr Foundation, the Sidney Kimmel Foundation for Cancer Research, The Cancer Research Institute, The Penelope London Fund, The Friedman Fund for Childhood Leukemia, and the G&P Foundation for Cancer Research. S.B. is supported by the New York University Molecular Oncology and Immunology training grant (T32 CA‑09161) and by an American Society of Haematology scholar award. We apologize for any omissions of key citations due to space constraints.",
year = "2008",
month = may,
doi = "10.1038/nri2304",
language = "English",
volume = "8",
pages = "380--390",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "5",
}