TY - JOUR
T1 - Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease
AU - Ray, William J.
AU - Ashall, Frank
AU - Goate, Alison M.
PY - 1998/4/1
Y1 - 1998/4/1
N2 - Our understanding of the pathogenesis of Alzheimer's disease (AD) comes primarily from the study of rare inherited forms of the disease. Mutations that cause familial AD appear to act by a common mechanism: that of increasing production of Aβ42/43, one of the family of Aβ peptides deposited in senile plaques. However, increased Aβ42/43 production has not been demonstrated to occur in most cases of sporadic AD, suggesting that genetic and environmental factors acting at other stages of the disease process can modify the risk for disease. Such factors most likely include those affecting Aβ aggregation or clearance, the inflammatory response, cerebrovascular disease, or susceptibility of neurons to injury. Identifying these factors will lead to a better understanding of the etiology of the disease and provide additional targets for therapeutic intervention.
AB - Our understanding of the pathogenesis of Alzheimer's disease (AD) comes primarily from the study of rare inherited forms of the disease. Mutations that cause familial AD appear to act by a common mechanism: that of increasing production of Aβ42/43, one of the family of Aβ peptides deposited in senile plaques. However, increased Aβ42/43 production has not been demonstrated to occur in most cases of sporadic AD, suggesting that genetic and environmental factors acting at other stages of the disease process can modify the risk for disease. Such factors most likely include those affecting Aβ aggregation or clearance, the inflammatory response, cerebrovascular disease, or susceptibility of neurons to injury. Identifying these factors will lead to a better understanding of the etiology of the disease and provide additional targets for therapeutic intervention.
UR - http://www.scopus.com/inward/record.url?scp=0031969718&partnerID=8YFLogxK
U2 - 10.1016/S1357-4310(98)01229-5
DO - 10.1016/S1357-4310(98)01229-5
M3 - Review article
C2 - 9572056
AN - SCOPUS:0031969718
SN - 1357-4310
VL - 4
SP - 151
EP - 157
JO - Molecular Medicine Today
JF - Molecular Medicine Today
IS - 4
ER -