TY - JOUR
T1 - Molecular mechanisms of opiate and cocaine addiction
AU - Nestler, Eric J.
N1 - Funding Information:
Preparation of this review was supported by grants from the National Institute on Drug Abuse (DA08227, DA00203, and DAI0160) and by the Abraham Ribicoff Research Facilities of the Connecticut Mental Health Center, State of Connecticut Department of Mental Health and Addiction Sen-ices.
PY - 1997/10
Y1 - 1997/10
N2 - Chronic administration of opiates or cocaine has been shown to alter the activity or expression of diverse types of cellular proteins in specific target neurons within the central nervous system. Prominent examples include signaling proteins, such as receptors, G proteins, second-messenger synthetic enzymes, and protein kinases. It is now increasingly possible to relate particular molecular adaptations to specific behavioral actions of drugs of abuse in animal models of addiction. In addition, recent work has focused on a role for transcription factors, and the associated alterations in gene expression, in mediating part of this long-lasting, drug-induced molecular and behavioral plasticity.
AB - Chronic administration of opiates or cocaine has been shown to alter the activity or expression of diverse types of cellular proteins in specific target neurons within the central nervous system. Prominent examples include signaling proteins, such as receptors, G proteins, second-messenger synthetic enzymes, and protein kinases. It is now increasingly possible to relate particular molecular adaptations to specific behavioral actions of drugs of abuse in animal models of addiction. In addition, recent work has focused on a role for transcription factors, and the associated alterations in gene expression, in mediating part of this long-lasting, drug-induced molecular and behavioral plasticity.
UR - http://www.scopus.com/inward/record.url?scp=0030727775&partnerID=8YFLogxK
U2 - 10.1016/S0959-4388(97)80094-3
DO - 10.1016/S0959-4388(97)80094-3
M3 - Article
C2 - 9384550
AN - SCOPUS:0030727775
SN - 0959-4388
VL - 7
SP - 713
EP - 719
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 5
ER -