Molecular mechanisms involved in initiation of the DNA damage response

Kevin J. Barnum, Matthew J. O’Connell

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response complexes at the DNA. Here, we review what is known about these processes for various DNA damage pathways.

Original languageEnglish
Article numbere970065
JournalMolecular and Cellular Oncology
Issue number1
StatePublished - 2 Jan 2015


  • DNA damage
  • checkpoint
  • excision
  • nuclease
  • recombination
  • repair
  • replication
  • transcription


Dive into the research topics of 'Molecular mechanisms involved in initiation of the DNA damage response'. Together they form a unique fingerprint.

Cite this