Molecular mechanisms involved in initiation of the DNA damage response

Kevin J. Barnum; Matthew J. O’Connell

doi:10.4161/23723548.2014.970065

Molecular mechanisms involved in initiation of the DNA damage response

Kevin J. Barnum, Matthew J. O’Connell

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response complexes at the DNA. Here, we review what is known about these processes for various DNA damage pathways.

Original language	English
Article number	e970065
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	1
DOIs	https://doi.org/10.4161/23723548.2014.970065
State	Published - 2 Jan 2015

Keywords

DNA damage
checkpoint
excision
nuclease
recombination
repair
replication
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10.4161/23723548.2014.970065

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title = "Molecular mechanisms involved in initiation of the DNA damage response",

abstract = "DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response complexes at the DNA. Here, we review what is known about these processes for various DNA damage pathways.",

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N2 - DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response complexes at the DNA. Here, we review what is known about these processes for various DNA damage pathways.

AB - DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response complexes at the DNA. Here, we review what is known about these processes for various DNA damage pathways.

KW - DNA damage

KW - checkpoint

KW - excision

KW - nuclease

KW - recombination

KW - repair

KW - replication

KW - transcription

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JF - Molecular and Cellular Oncology

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M1 - e970065

ER -

Molecular mechanisms involved in initiation of the DNA damage response

Abstract

Keywords

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