Molecular markers of carcinogenesis

Paul W. Brandt-Rauf; Matthew R. Pincus

doi:10.1016/S0163-7258(97)00111-3

Molecular markers of carcinogenesis

Paul W. Brandt-Rauf, Matthew R. Pincus

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

The protein products of oncogenes and tumor suppressor genes play critical roles in the development of many cancers. The expression of a number of these proteins can be detected in extracellular fluids such as blood. This article reviews the literature on the application of methods for the detection of the proteins of oncogenes and tumor suppressor genes in the blood of humans with cancer or at risk for the development of cancer. The detection of these proteins in blood may be useful molecular markers of carcinogenesis that could play an important part in cancer diagnosis, prognosis, and prevention.

Original language	English
Pages (from-to)	135-148
Number of pages	14
Journal	Pharmacology and Therapeutics
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/S0163-7258(97)00111-3
State	Published - Feb 1998
Externally published	Yes

Keywords

Cancer
Growth factors
Oncogene proteins
Tumor suppressor gene proteins

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10.1016/S0163-7258(97)00111-3

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@article{e6ec6b38b6864f128d58472f30163c92,

title = "Molecular markers of carcinogenesis",

abstract = "The protein products of oncogenes and tumor suppressor genes play critical roles in the development of many cancers. The expression of a number of these proteins can be detected in extracellular fluids such as blood. This article reviews the literature on the application of methods for the detection of the proteins of oncogenes and tumor suppressor genes in the blood of humans with cancer or at risk for the development of cancer. The detection of these proteins in blood may be useful molecular markers of carcinogenesis that could play an important part in cancer diagnosis, prognosis, and prevention.",

keywords = "Cancer, Growth factors, Oncogene proteins, Tumor suppressor gene proteins",

author = "Brandt-Rauf, \{Paul W.\} and Pincus, \{Matthew R.\}",

note = "Funding Information: This work was supported in part by grants from the National Cancer Institute (R01-CA42500 and R01-CA69423) and the Environmental Protection Agency (R-825361).",

year = "1998",

month = feb,

doi = "10.1016/S0163-7258(97)00111-3",

language = "English",

volume = "77",

pages = "135--148",

journal = "Pharmacology and Therapeutics",

issn = "0163-7258",

publisher = "Elsevier Inc.",

number = "2",

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TY - JOUR

T1 - Molecular markers of carcinogenesis

AU - Brandt-Rauf, Paul W.

AU - Pincus, Matthew R.

N1 - Funding Information: This work was supported in part by grants from the National Cancer Institute (R01-CA42500 and R01-CA69423) and the Environmental Protection Agency (R-825361).

PY - 1998/2

Y1 - 1998/2

N2 - The protein products of oncogenes and tumor suppressor genes play critical roles in the development of many cancers. The expression of a number of these proteins can be detected in extracellular fluids such as blood. This article reviews the literature on the application of methods for the detection of the proteins of oncogenes and tumor suppressor genes in the blood of humans with cancer or at risk for the development of cancer. The detection of these proteins in blood may be useful molecular markers of carcinogenesis that could play an important part in cancer diagnosis, prognosis, and prevention.

AB - The protein products of oncogenes and tumor suppressor genes play critical roles in the development of many cancers. The expression of a number of these proteins can be detected in extracellular fluids such as blood. This article reviews the literature on the application of methods for the detection of the proteins of oncogenes and tumor suppressor genes in the blood of humans with cancer or at risk for the development of cancer. The detection of these proteins in blood may be useful molecular markers of carcinogenesis that could play an important part in cancer diagnosis, prognosis, and prevention.

KW - Cancer

KW - Growth factors

KW - Oncogene proteins

KW - Tumor suppressor gene proteins

UR - https://www.scopus.com/pages/publications/0031887471

U2 - 10.1016/S0163-7258(97)00111-3

DO - 10.1016/S0163-7258(97)00111-3

M3 - Review article

C2 - 9578321

AN - SCOPUS:0031887471

SN - 0163-7258

VL - 77

SP - 135

EP - 148

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

IS - 2

ER -

Molecular markers of carcinogenesis

Abstract

Keywords

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