Molecular identification of adenoviruses in clinical samples by analyzing a partial hexon genomic region

I. Casas, A. Avellon, M. Mosquera, O. Jabado, J. E. Echevarria, R. H. Campos, M. Rewers, P. Perez-Breña, W. I. Lipkin, G. Palacios

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Here we present a system for adenovirus detection and genotyping based on PCR amplification and phylogenetic analysis of a conserved hexon gene fragment. The system was validated using 157 sequences (86 previously typed and 71 clinical samples) and correctly identified species and serotype in 100% and 84% of sequences, respectively. Known associations between specific serotypes and clinical syndromes are verified. Possible new associations are described to allow further independent testing.

Original languageEnglish
Pages (from-to)6176-6182
Number of pages7
JournalJournal of Clinical Microbiology
Volume43
Issue number12
DOIs
StatePublished - Dec 2005
Externally publishedYes

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