Molecular dissection of transcriptional control elements within the long terminal repeat of the retrovirus

A. Srinivasan; E. Premkumar Reddy; Claire Y. Dunn; Stuart A. Aaronson

doi:10.1126/science.6322296

Molecular dissection of transcriptional control elements within the long terminal repeat of the retrovirus

A. Srinivasan, E. Premkumar Reddy, Claire Y. Dunn, Stuart A. Aaronson

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The retroviral long terminal repeat (LTR) contains transcriptional control elements that affect viral gene expression. By deletion mutagenesis of the genome of the cloned Abelson murine leukemia virus, regulatory signals could be mapped to at least three domains within the LTR. A defective 5′ LTR that did not sustain transforming gene function was complemented by an intact LTR positioned at the 3′ end of the genotne. This versatility of the retroviral genome with respect to its transcriptional control elements appears to provide a strong selective advantage for viral gene expression.

Original language	English
Pages (from-to)	286-289
Number of pages	4
Journal	Science
Volume	223
Issue number	4633
DOIs	https://doi.org/10.1126/science.6322296
State	Published - 1984
Externally published	Yes

Access to Document

10.1126/science.6322296

Cite this

@article{5e7c535a186c4a8eb48b2df4f6719151,

title = "Molecular dissection of transcriptional control elements within the long terminal repeat of the retrovirus",

abstract = "The retroviral long terminal repeat (LTR) contains transcriptional control elements that affect viral gene expression. By deletion mutagenesis of the genome of the cloned Abelson murine leukemia virus, regulatory signals could be mapped to at least three domains within the LTR. A defective 5′ LTR that did not sustain transforming gene function was complemented by an intact LTR positioned at the 3′ end of the genotne. This versatility of the retroviral genome with respect to its transcriptional control elements appears to provide a strong selective advantage for viral gene expression.",

author = "A. Srinivasan and Reddy, \{E. Premkumar\} and Dunn, \{Claire Y.\} and Aaronson, \{Stuart A.\}",

year = "1984",

doi = "10.1126/science.6322296",

language = "English",

volume = "223",

pages = "286--289",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4633",

}

TY - JOUR

T1 - Molecular dissection of transcriptional control elements within the long terminal repeat of the retrovirus

AU - Srinivasan, A.

AU - Reddy, E. Premkumar

AU - Dunn, Claire Y.

AU - Aaronson, Stuart A.

PY - 1984

Y1 - 1984

N2 - The retroviral long terminal repeat (LTR) contains transcriptional control elements that affect viral gene expression. By deletion mutagenesis of the genome of the cloned Abelson murine leukemia virus, regulatory signals could be mapped to at least three domains within the LTR. A defective 5′ LTR that did not sustain transforming gene function was complemented by an intact LTR positioned at the 3′ end of the genotne. This versatility of the retroviral genome with respect to its transcriptional control elements appears to provide a strong selective advantage for viral gene expression.

AB - The retroviral long terminal repeat (LTR) contains transcriptional control elements that affect viral gene expression. By deletion mutagenesis of the genome of the cloned Abelson murine leukemia virus, regulatory signals could be mapped to at least three domains within the LTR. A defective 5′ LTR that did not sustain transforming gene function was complemented by an intact LTR positioned at the 3′ end of the genotne. This versatility of the retroviral genome with respect to its transcriptional control elements appears to provide a strong selective advantage for viral gene expression.

UR - https://www.scopus.com/pages/publications/0021357805

U2 - 10.1126/science.6322296

DO - 10.1126/science.6322296

M3 - Article

C2 - 6322296

AN - SCOPUS:0021357805

SN - 0036-8075

VL - 223

SP - 286

EP - 289

JO - Science

JF - Science

IS - 4633

ER -

Molecular dissection of transcriptional control elements within the long terminal repeat of the retrovirus

Abstract

Access to Document

Fingerprint

Cite this