Molecular cloning and physical characterization of integrated equine infectious anemia virus: Molecular and immunologic evidence of its close relationship to ovine and caprine lentiviruses

Abraham Yaniv; John Dahlberg; Arnona Gazit; Levana Sherman; Ing Ming Chiu; Steven R. Tronick; Stuart A. Aaronson

doi:10.1016/0042-6822(86)90424-1

Molecular cloning and physical characterization of integrated equine infectious anemia virus: Molecular and immunologic evidence of its close relationship to ovine and caprine lentiviruses

Abraham Yaniv, John Dahlberg, Arnona Gazit, Levana Sherman, Ing Ming Chiu, Steven R. Tronick, Stuart A. Aaronson

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Molecular clones of the integrated form of the genome of equine infectious anemia virus (EIAV), the etiologic agent of a naturally occurring, worldwide disease of horses, were obtained. The restriction map of a full-length genome was determined. Additional evidence for the close evolutionary relationship between EIAV and a prototype lentivirus (caprine arthritis encephalitis virus) was acquired by Southern blotting and immunological analyses. An interspecies radioimmunoassay was developed in which EIAV and ovine and caprine lentiviruses could be detected equally well. These studies make available precisely defined reagents to pursue the study of the mechanisms of pathogenesis of lentiviral induced diseases.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Virology
Volume	154
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(86)90424-1
State	Published - 15 Oct 1986
Externally published	Yes

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AU - Gazit, Arnona

AU - Sherman, Levana

AU - Chiu, Ing Ming

AU - Tronick, Steven R.

AU - Aaronson, Stuart A.

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Molecular cloning and physical characterization of integrated equine infectious anemia virus: Molecular and immunologic evidence of its close relationship to ovine and caprine lentiviruses

Abstract

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