TY - JOUR
T1 - Molecular characterization of an early invasive staphylococcus epidermidis prosthetic joint infection
AU - Rosenthal, Marnie E.
AU - Dever, Lisa L.
AU - Moucha, Calin S.
AU - Chavda, Kalyan D.
AU - Otto, Michael
AU - Kreiswirth, Barry N.
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Historically regarded as a skin commensal, Staphylococcus epidermidis has been increasingly implicated in invasive foreign body infections such as catheter-related bloodstream infections, indwelling device infections, and prosthetic joint infections. We report a case of an aggressive, difficult-to-eradicate, invasive prosthetic hip infection occurring early after hardware implant and associated with a high-grade bacteremia and assess its salient molecular characteristics. The clinical and molecular characteristics of this isolate mirror the pathogenesis and persistence commonly seen with invasive methicillin-resistant S. aureus and may be attributed to the combination of resistance genes (SCCmec type IV), putative virulence factors (arcA and opp3a), cytolytic peptide production (α-type phenol-soluble modulins), and biofilm adhesion, interaction, and maturation (bhp, aap, and β-type phenol-soluble modulins).
AB - Historically regarded as a skin commensal, Staphylococcus epidermidis has been increasingly implicated in invasive foreign body infections such as catheter-related bloodstream infections, indwelling device infections, and prosthetic joint infections. We report a case of an aggressive, difficult-to-eradicate, invasive prosthetic hip infection occurring early after hardware implant and associated with a high-grade bacteremia and assess its salient molecular characteristics. The clinical and molecular characteristics of this isolate mirror the pathogenesis and persistence commonly seen with invasive methicillin-resistant S. aureus and may be attributed to the combination of resistance genes (SCCmec type IV), putative virulence factors (arcA and opp3a), cytolytic peptide production (α-type phenol-soluble modulins), and biofilm adhesion, interaction, and maturation (bhp, aap, and β-type phenol-soluble modulins).
UR - http://www.scopus.com/inward/record.url?scp=80052242805&partnerID=8YFLogxK
U2 - 10.1089/mdr.2010.0157
DO - 10.1089/mdr.2010.0157
M3 - Article
C2 - 21510745
AN - SCOPUS:80052242805
SN - 1076-6294
VL - 17
SP - 345
EP - 350
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
IS - 3
ER -