Modulation of neuroeffector transmission in the guinea pig pulmonary artery by endogenous nitric oxide

Bo Cederqvist; N. Peter Wiklund; Magnus G. Persson; Lars E. Gustafsson

doi:10.1016/0304-3940(91)90896-2

Modulation of neuroeffector transmission in the guinea pig pulmonary artery by endogenous nitric oxide

Bo Cederqvist, N. Peter Wiklund, Magnus G. Persson, Lars E. Gustafsson

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The influence of endogenous nitric oxide (NO) on neuroeffector transmission in segments of guinea pig pulmonary artery was analyzed by application of N^G-monomethyl-l-argining (l-NMMA). l-NMMA enhanced contractile responses to nerve stimulation and this enhancement was counteracted by l-arginine. The enhancement remained after removal of the endothelium. l-NMMA enhanced contractions to exogenous noradrenaline. After blockade of adrenergic transmission by phentolamine, l-NMMA enhanced contractions induced by nonadrenergic-noncholinergic (NANC) neurotransmission. Stimulation-induced release of [³H]noradrenaline was unchanged by l-NMMA. The results suggest that endogenous NO exerts a postjunctional inhibition on adrenergic neurotransmission in the guinea pig pulmonary artery. A concomitant pre- and/or postjunctional inhibition of NANC transmission is implicated. The neuromodulation by NO does not require an intact endothelium.

Original language	English
Pages (from-to)	67-69
Number of pages	3
Journal	Neuroscience Letters
Volume	127
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90896-2
State	Published - 10 Jun 1991
Externally published	Yes

Keywords

EDRF
N-Monomethyl-l-arginine
Nitric oxide
Nonadrenergic-noncholinergic neurotransmission
Noradrenaline release
Smooth muscle

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title = "Modulation of neuroeffector transmission in the guinea pig pulmonary artery by endogenous nitric oxide",

abstract = "The influence of endogenous nitric oxide (NO) on neuroeffector transmission in segments of guinea pig pulmonary artery was analyzed by application of NG-monomethyl-l-argining (l-NMMA). l-NMMA enhanced contractile responses to nerve stimulation and this enhancement was counteracted by l-arginine. The enhancement remained after removal of the endothelium. l-NMMA enhanced contractions to exogenous noradrenaline. After blockade of adrenergic transmission by phentolamine, l-NMMA enhanced contractions induced by nonadrenergic-noncholinergic (NANC) neurotransmission. Stimulation-induced release of [3H]noradrenaline was unchanged by l-NMMA. The results suggest that endogenous NO exerts a postjunctional inhibition on adrenergic neurotransmission in the guinea pig pulmonary artery. A concomitant pre- and/or postjunctional inhibition of NANC transmission is implicated. The neuromodulation by NO does not require an intact endothelium.",

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AU - Cederqvist, Bo

AU - Wiklund, N. Peter

AU - Persson, Magnus G.

AU - Gustafsson, Lars E.

PY - 1991/6/10

Y1 - 1991/6/10

N2 - The influence of endogenous nitric oxide (NO) on neuroeffector transmission in segments of guinea pig pulmonary artery was analyzed by application of NG-monomethyl-l-argining (l-NMMA). l-NMMA enhanced contractile responses to nerve stimulation and this enhancement was counteracted by l-arginine. The enhancement remained after removal of the endothelium. l-NMMA enhanced contractions to exogenous noradrenaline. After blockade of adrenergic transmission by phentolamine, l-NMMA enhanced contractions induced by nonadrenergic-noncholinergic (NANC) neurotransmission. Stimulation-induced release of [3H]noradrenaline was unchanged by l-NMMA. The results suggest that endogenous NO exerts a postjunctional inhibition on adrenergic neurotransmission in the guinea pig pulmonary artery. A concomitant pre- and/or postjunctional inhibition of NANC transmission is implicated. The neuromodulation by NO does not require an intact endothelium.

AB - The influence of endogenous nitric oxide (NO) on neuroeffector transmission in segments of guinea pig pulmonary artery was analyzed by application of NG-monomethyl-l-argining (l-NMMA). l-NMMA enhanced contractile responses to nerve stimulation and this enhancement was counteracted by l-arginine. The enhancement remained after removal of the endothelium. l-NMMA enhanced contractions to exogenous noradrenaline. After blockade of adrenergic transmission by phentolamine, l-NMMA enhanced contractions induced by nonadrenergic-noncholinergic (NANC) neurotransmission. Stimulation-induced release of [3H]noradrenaline was unchanged by l-NMMA. The results suggest that endogenous NO exerts a postjunctional inhibition on adrenergic neurotransmission in the guinea pig pulmonary artery. A concomitant pre- and/or postjunctional inhibition of NANC transmission is implicated. The neuromodulation by NO does not require an intact endothelium.

KW - EDRF

KW - N-Monomethyl-l-arginine

KW - Nitric oxide

KW - Nonadrenergic-noncholinergic neurotransmission

KW - Noradrenaline release

KW - Smooth muscle

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JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

Modulation of neuroeffector transmission in the guinea pig pulmonary artery by endogenous nitric oxide

Abstract

Keywords

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