Modulation of autonomic neuroeffector transmission by nitric oxide-like activity in guinea-pig smooth muscle

L. E. Gustafsson, N. P. Wiklund, C. U. Wiklund, B. Cederqvist, M. G. P ersson, S. Moncada

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

20 Scopus citations

Abstract

A possible neuromodulator role of endogenous nitric oxide (NO) formed from the amino acid L-arginine in guinea-pig ileum, pulmonary artery and taenia coli was studied using N(G)-monomethyl-L-arginine (L-NMMA). L-NMMA enhanced nerve-induced contractions in the ileum and pulmonary artery whereas it partially inhibited the relaxations in the taenia coli. This indicates that endogenous NO, or a similar entity formed from L-arginine, exerts neuromodulatory effects in these tissues, lending further support to the hypothesis that NO is important for intercellular communication. The neuromodulatory effect of NO is probably exerted via both pre- and postjunctional mechanisms.

Original languageEnglish
Title of host publicationNitric oxide from L-arginine
Subtitle of host publicationa bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897
EditorsS. Moncada, E.A. Higgs, S. Moncada, E.A. Higgs
PublisherElsevier Science Publishers B.V.
Pages177-181
Number of pages5
ISBN (Print)0444811540
StatePublished - 1990
Externally publishedYes
EventA Symposium on Biological Importance of Nitric Oxide -
Duration: 14 Sep 198915 Sep 1989

Publication series

NameNitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897

Conference

ConferenceA Symposium on Biological Importance of Nitric Oxide
Period14/09/8915/09/89

Fingerprint

Dive into the research topics of 'Modulation of autonomic neuroeffector transmission by nitric oxide-like activity in guinea-pig smooth muscle'. Together they form a unique fingerprint.

Cite this