A possible neuromodulator role of endogenous nitric oxide (NO) formed from the amino acid L-arginine in guinea-pig ileum, pulmonary artery and taenia coli was studied using N(G)-monomethyl-L-arginine (L-NMMA). L-NMMA enhanced nerve-induced contractions in the ileum and pulmonary artery whereas it partially inhibited the relaxations in the taenia coli. This indicates that endogenous NO, or a similar entity formed from L-arginine, exerts neuromodulatory effects in these tissues, lending further support to the hypothesis that NO is important for intercellular communication. The neuromodulatory effect of NO is probably exerted via both pre- and postjunctional mechanisms.
|Title of host publication
|Nitric oxide from L-arginine
|Subtitle of host publication
|a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897
|S. Moncada, E.A. Higgs, S. Moncada, E.A. Higgs
|Elsevier Science Publishers B.V.
|Number of pages
|Published - 1990
|A Symposium on Biological Importance of Nitric Oxide -
Duration: 14 Sep 1989 → 15 Sep 1989
|Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897
|A Symposium on Biological Importance of Nitric Oxide
|14/09/89 → 15/09/89