Modulation of alpha interferon levels by AZT treatment in HIV-seropositive patients.

E. Buimovici-Klein, G. F. McKinley, M. Lange, J. A. Sonnabend, V. Mohan, M. H. Grieco, L. Z. Cooper

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The effect of AZT on serum HIV p24 antigen and endogenous serum alpha interferon levels was studied in AIDS and ARC patients. Following administration of AZT there was a rapid decline in the serum levels of both HIV p24 antigen and alpha interferon. When AZT treatment was interrupted, the levels of both HIV p24 antigen and of interferon rapidly increased. These findings suggest that HIV or some other AZT sensitive microorganism is the inducer of interferon which is characteristically found in the serum of AIDS and symptomatic HIV infected patients. They also suggest that the rapid decline in interferon levels may underlie some of the symptomatic benefit that follows administration of AZT.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalJournal of Experimental Pathology
Volume6
Issue number1-2
StatePublished - 1992
Externally publishedYes

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