Modulation of accelerated rat cardiac allograft rejection by cyclosporine and ART-18

R. DiStefano; J. W. Kupiec-Weglinski; L. C. Uhteg; J. Puskas; D. Araneda; T. Diamantstein; N. L. Tilney

Modulation of accelerated rat cardiac allograft rejection by cyclosporine and ART-18

R. DiStefano
, J. W. Kupiec-Weglinski
, L. C. Uhteg
, J. Puskas
, D. Araneda
, T. Diamantstein
, N. L. Tilney

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We have developed an experimental model in which cardiac allografts are uniformly rejected in an accelerated fashion within 48 hours by presensitized rats. We have also attempted to modulate this fulminant humoral and cellular host immune response using cyclosporine (CsA) and ART-18, a monoclonal antibody directed against the interleukin 2 receptor (IL 2R MoAb) molecule expressed primarily on activated but not resting T lymphocytes. As these therapies have been useful in prolonging graft survival in unsensitized hosts, they have been tested in this system.

Original language	English
Pages (from-to)	217-222
Number of pages	6
Journal	Transplantation Proceedings
Volume	20
Issue number	2 SUPPL. 2
State	Published - 1988
Externally published	Yes

Cite this

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title = "Modulation of accelerated rat cardiac allograft rejection by cyclosporine and ART-18",

abstract = "We have developed an experimental model in which cardiac allografts are uniformly rejected in an accelerated fashion within 48 hours by presensitized rats. We have also attempted to modulate this fulminant humoral and cellular host immune response using cyclosporine (CsA) and ART-18, a monoclonal antibody directed against the interleukin 2 receptor (IL 2R MoAb) molecule expressed primarily on activated but not resting T lymphocytes. As these therapies have been useful in prolonging graft survival in unsensitized hosts, they have been tested in this system.",

author = "R. DiStefano and Kupiec-Weglinski, \{J. W.\} and Uhteg, \{L. C.\} and J. Puskas and D. Araneda and T. Diamantstein and Tilney, \{N. L.\}",

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AU - DiStefano, R.

AU - Kupiec-Weglinski, J. W.

AU - Uhteg, L. C.

AU - Puskas, J.

AU - Araneda, D.

AU - Diamantstein, T.

AU - Tilney, N. L.

PY - 1988

Y1 - 1988

N2 - We have developed an experimental model in which cardiac allografts are uniformly rejected in an accelerated fashion within 48 hours by presensitized rats. We have also attempted to modulate this fulminant humoral and cellular host immune response using cyclosporine (CsA) and ART-18, a monoclonal antibody directed against the interleukin 2 receptor (IL 2R MoAb) molecule expressed primarily on activated but not resting T lymphocytes. As these therapies have been useful in prolonging graft survival in unsensitized hosts, they have been tested in this system.

AB - We have developed an experimental model in which cardiac allografts are uniformly rejected in an accelerated fashion within 48 hours by presensitized rats. We have also attempted to modulate this fulminant humoral and cellular host immune response using cyclosporine (CsA) and ART-18, a monoclonal antibody directed against the interleukin 2 receptor (IL 2R MoAb) molecule expressed primarily on activated but not resting T lymphocytes. As these therapies have been useful in prolonging graft survival in unsensitized hosts, they have been tested in this system.

UR - https://www.scopus.com/pages/publications/0023937418

M3 - Article

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AN - SCOPUS:0023937418

SN - 0041-1345

VL - 20

SP - 217

EP - 222

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 2 SUPPL. 2

ER -

Modulation of accelerated rat cardiac allograft rejection by cyclosporine and ART-18

Abstract

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