TY - JOUR
T1 - Modulation of a number of genes on personality traits in a sample of healthy subjects
AU - Calati, Raffaella
AU - Signorelli, Maria Salvina
AU - Gressier, Florence
AU - Bianchini, Oriana
AU - Porcelli, Stefano
AU - Comings, David E.
AU - Girolamo, Giovanni De
AU - Aguglia, Eugenio
AU - MacMurray, James
AU - Serretti, Alessandro
PY - 2014/4/30
Y1 - 2014/4/30
N2 - A large number of studies investigated the genetic modulation of personality with mixed results. As a confirmatory analysis of previous findings, we firstly examined the association between several previously examined single nucleotide polymorphisms (SNPs) and personality traits in a sample of 158 healthy subjects. As a secondary aim, we tested the potential modulation of additional never previously investigated genes on personality. A blood sample was collected and the Temperament and Character Inventory (TCI) has been administered to all participants. Multivariate analysis of covariance, controlling for sex and age, was used to test SNP influence on TCI scores. Examination of previously studied gene variants showed an effect of adrenergic alpha 2B receptor (ADRA2B) on Cooperativeness and of serotonin receptor HTR2A on Self Directedness. Examination of new variants revealed that sex hormone binding protein (SHBG) was associated with reward dependence. Moreover, several additional variants showed a tendency towards association with some TCI traits, confirming previous results. This study suggests that ADRA2B, HTR2A and SHBG genes may be involved in the modulation of personality in healthy subjects. The major limitation of this study was the small sample size.
AB - A large number of studies investigated the genetic modulation of personality with mixed results. As a confirmatory analysis of previous findings, we firstly examined the association between several previously examined single nucleotide polymorphisms (SNPs) and personality traits in a sample of 158 healthy subjects. As a secondary aim, we tested the potential modulation of additional never previously investigated genes on personality. A blood sample was collected and the Temperament and Character Inventory (TCI) has been administered to all participants. Multivariate analysis of covariance, controlling for sex and age, was used to test SNP influence on TCI scores. Examination of previously studied gene variants showed an effect of adrenergic alpha 2B receptor (ADRA2B) on Cooperativeness and of serotonin receptor HTR2A on Self Directedness. Examination of new variants revealed that sex hormone binding protein (SHBG) was associated with reward dependence. Moreover, several additional variants showed a tendency towards association with some TCI traits, confirming previous results. This study suggests that ADRA2B, HTR2A and SHBG genes may be involved in the modulation of personality in healthy subjects. The major limitation of this study was the small sample size.
KW - Character
KW - Genetics
KW - Personality
KW - TCI
KW - Temperament
UR - https://www.scopus.com/pages/publications/84897412335
U2 - 10.1016/j.neulet.2014.02.001
DO - 10.1016/j.neulet.2014.02.001
M3 - Article
C2 - 24530258
AN - SCOPUS:84897412335
SN - 0304-3940
VL - 566
SP - 320
EP - 325
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -