Modulating molecular functions of p53 with small molecules

Shiraz Mujtaba; Lei Zeng; Ming Ming Zhou

doi:10.4161/cc.5.22.3464

Modulating molecular functions of p53 with small molecules

Shiraz Mujtaba, Lei Zeng, Ming Ming Zhou

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Association of the human tumor suppressor p53 with many human cancers makes it a valuable therapeutic target. Stress-induced molecular interactions of p53 with other effector proteins are immensely intertwined with regulation of its functions in orchestrating a wide array of cellular responses, thereby defying analysis of the underlying molecular mechanisms with conventional molecular and cellular biology methods. Recent discoveries of small molecules that can selectively modulate the molecular interactions of p53 offer promising opportunities to address the challenge of dissecting these complex mechanisms and increase the hope for pharmacological control of p53 for clinical benefits of cancer patients.

Original language	English
Pages (from-to)	2575-2578
Number of pages	4
Journal	Cell Cycle
Volume	5
Issue number	22
DOIs	https://doi.org/10.4161/cc.5.22.3464
State	Published - 15 Nov 2006
Externally published	Yes

Keywords

Bromodomain
CREB-binding protein (CBP)
Lysine acetylation
Small molecules
Tumor suppressor p53

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title = "Modulating molecular functions of p53 with small molecules",

abstract = "Association of the human tumor suppressor p53 with many human cancers makes it a valuable therapeutic target. Stress-induced molecular interactions of p53 with other effector proteins are immensely intertwined with regulation of its functions in orchestrating a wide array of cellular responses, thereby defying analysis of the underlying molecular mechanisms with conventional molecular and cellular biology methods. Recent discoveries of small molecules that can selectively modulate the molecular interactions of p53 offer promising opportunities to address the challenge of dissecting these complex mechanisms and increase the hope for pharmacological control of p53 for clinical benefits of cancer patients.",

keywords = "Bromodomain, CREB-binding protein (CBP), Lysine acetylation, Small molecules, Tumor suppressor p53",

author = "Shiraz Mujtaba and Lei Zeng and Zhou, {Ming Ming}",

note = "Funding Information: This work was supported by grants from the National Institutes of Health to M.-M.Z. and S.M.",

year = "2006",

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doi = "10.4161/cc.5.22.3464",

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T1 - Modulating molecular functions of p53 with small molecules

AU - Mujtaba, Shiraz

AU - Zeng, Lei

AU - Zhou, Ming Ming

N1 - Funding Information: This work was supported by grants from the National Institutes of Health to M.-M.Z. and S.M.

PY - 2006/11/15

Y1 - 2006/11/15

N2 - Association of the human tumor suppressor p53 with many human cancers makes it a valuable therapeutic target. Stress-induced molecular interactions of p53 with other effector proteins are immensely intertwined with regulation of its functions in orchestrating a wide array of cellular responses, thereby defying analysis of the underlying molecular mechanisms with conventional molecular and cellular biology methods. Recent discoveries of small molecules that can selectively modulate the molecular interactions of p53 offer promising opportunities to address the challenge of dissecting these complex mechanisms and increase the hope for pharmacological control of p53 for clinical benefits of cancer patients.

AB - Association of the human tumor suppressor p53 with many human cancers makes it a valuable therapeutic target. Stress-induced molecular interactions of p53 with other effector proteins are immensely intertwined with regulation of its functions in orchestrating a wide array of cellular responses, thereby defying analysis of the underlying molecular mechanisms with conventional molecular and cellular biology methods. Recent discoveries of small molecules that can selectively modulate the molecular interactions of p53 offer promising opportunities to address the challenge of dissecting these complex mechanisms and increase the hope for pharmacological control of p53 for clinical benefits of cancer patients.

KW - Bromodomain

KW - CREB-binding protein (CBP)

KW - Lysine acetylation

KW - Small molecules

KW - Tumor suppressor p53

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U2 - 10.4161/cc.5.22.3464

DO - 10.4161/cc.5.22.3464

M3 - Review article

C2 - 17172837

AN - SCOPUS:33751229283

SN - 1538-4101

VL - 5

SP - 2575

EP - 2578

JO - Cell Cycle

JF - Cell Cycle

IS - 22

ER -

Modulating molecular functions of p53 with small molecules

Abstract

Keywords

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