Modulación del cambio de isotipo de las inmunoglobulinas por señales del sistema inmunitario innato

Translated title of the contribution: Immunoglobulin class switch recombination by innate immune system signals

Irene Puga, Andrea Cerutti, Montserrat Cols

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


Mature B cells emerge from the bone marrow and continue to diversify their immunoglobulin genes through 2 antigen-dependent processes known as somatic hypermutation and class switch recombination. These processes require AID, a DNA-editing enzyme. Although both processes predominantly occur in germinal center B cells engaged in a T cell-dependent (TD) antibody response against protein antigens recent, evidence shows that B cells receive additional help from invariant natural killer T cells, dendritic cells, and various granulocytes, including neutrophils, eosinophils, and basophils. These innate immune cells enhance TD antibody responses by delivering B-cell helper signals whether in germinal centers, postgerminal lymphoid centers, or the bone marrow. In addition to enhancing and complementing the B-cell helper activity of canonical T cells, invariant natural killer T cells, dendritic cells, and granulocytes can deliver T cell-independent B-cell helper signals at the mucosal interface and in the marginal zone of the spleen to initiate rapid innate-like antibody responses. In this review, we discuss recent advances in the role of innate cells in B-cell helper signals and in antibody diversification and production.

Translated title of the contributionImmunoglobulin class switch recombination by innate immune system signals
Original languageSpanish
Pages (from-to)11-18
Number of pages8
JournalSeminarios de la Fundacion Espanola de Reumatologia
Issue number1
StatePublished - Jan 2014


  • A proliferation-inducing ligand
  • B cells
  • B-cell activating factor
  • Class switching
  • Immunoglobulins
  • Innate immune system
  • Toll-like receptors


Dive into the research topics of 'Immunoglobulin class switch recombination by innate immune system signals'. Together they form a unique fingerprint.

Cite this