Modified poly-L-lactic acid injection technique safety and efficacy of "cross-fanning" in non-HIV-related facial atrophy

Jonathan Y. Lee, Matthew R. Schulman, Richard A. Skolnik

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Proper injection of poly-L-lactic acid has a role in avoiding development of subcutaneous papules. We evaluated the safety and efficacy of our injection technique ("cross-fanning") and compared it to 4 previous studies. Forty patients were evaluated for adverse events (bruising, edema, erythema, subcutaneous papules) and satisfaction. Papule incidence was compared with the other studies. The incidence of papules (4/40) was significantly lower than that of VEGA and Chelsea and Westminster (P = 0.00003, P = 0.03), but not significantly different than APEX002 or Blue Pacific (P = 0.42, P = 0.61). Bruising (5/40), edema (2/40), papules (4/40), and patient self-satisfaction (80%, P = 0.0001) was also documented. We maintain that cross-fanning has an excellent safety profile and patient satisfaction rate. We also maintain that our modified technique has advantages over the recommended "tunneling cross-hatch" and "depot" technique. Because 38 of 40 patients were HIV-negative, this study also represents the first single-practice series of proper injection of poly-L-lactic acid administration in the immuno-competent patient.

Original languageEnglish
Pages (from-to)435-441
Number of pages7
JournalAnnals of Plastic Surgery
Volume64
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

Keywords

  • Cross-fanning
  • Cross-tunneling
  • Granuloma
  • HIV
  • Injection technique
  • Lipoatrophy
  • Poly-L-lactic acid
  • Sculptra
  • Subcutaneous papules

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