Modification of the diabetes prevention program for the treatment of nonalcoholic fatty liver disease: A pilot study

Melissa Hershman, Karen Torbjornsen, Daniel Pang, Brooke Wyatt, Douglas T. Dieterich, Ponni V. Perumalswami, Andrea D. Branch, Amreen M. Dinani

Research output: Contribution to journalArticlepeer-review


Objective: The Diabetes Prevention Program (DPP) is the gold standard lifestyle modification program that reduces incident type 2 diabetes mellitus. Patients with prediabetes and patients with non-alcoholic fatty liver disease (NAFLD) often share metabolic features; we hypothesized that the DPP could be adapted and used to improve outcomes in patients with NAFLD. Methods: NAFLD patients were recruited into a 1 year modified DPP. Demographics, medical comorbidities, and clinical laboratory values were collected at baseline, 6 and 12 months. The primary endpoint was change in weight at 12 months. Secondary endpoints were changes in hepatic steatosis, metabolic comorbidities, and liver enzymes (per-protocol basis) and retention at 6 and 12 months. Results: Fourteen NAFLD patients enrolled; three dropped out before 6 months. From baseline to 12 months, hepatic steatosis (p = 0.03), alanine aminotransferase (p = 0.02), aspartate aminotransferase (p = 0.02), high-density lipoprotein (p = 0.01) and NAFLD fibrosis score (p < 0.001) improved, but low-density lipoprotein worsened (p = 0.04). Conclusion: Seventy-nine percent of patients completed the modified DPP. Patients lost weight and had improvements in five out of six indicators of liver injury and lipid metabolism. Clinical Trial Registry Number: NCT04988204.

Original languageEnglish
Pages (from-to)218-225
Number of pages8
JournalObesity Science and Practice
Issue number3
StatePublished - Jun 2023


  • diabetes prevention program
  • lifestyle intervention
  • nonalcoholic fatty liver disease
  • weight loss


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