Models of cardiac excitation-contraction coupling in ventricular myocytes

George S.B. Williams, Gregory D. Smith, Eric A. Sobie, M. Saleet Jafri

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Mathematical and computational modeling of cardiac excitation-contraction coupling has produced considerable insights into how the heart muscle contracts. With the increase in biophysical and physiological data available, the modeling has become more sophisticated with investigations spanning in scale from molecular components to whole cells. These modeling efforts have provided insight into cardiac excitation-contraction coupling that advanced and complemented experimental studies. One goal is to extend these detailed cellular models to model the whole heart. While this has been done with mechanical and electophysiological models, the complexity and fast time course of calcium dynamics have made inclusion of detailed calcium dynamics in whole heart models impractical. Novel methods such as the probability density approach and moment closure technique which increase computational efficiency might make this tractable.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalMathematical Biosciences
Volume226
Issue number1
DOIs
StatePublished - Jul 2010

Keywords

  • Calcium
  • Calcium spark
  • Excitation-contraction coupling
  • Heart
  • Model

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