Modeling the dynamics of bivalent histone modifications

Wai Lim Ku; Michelle Girvan; Guo Cheng Yuan; Francesco Sorrentino; Edward Ott

doi:10.1371/journal.pone.0077944

Modeling the dynamics of bivalent histone modifications

Wai Lim Ku, Michelle Girvan, Guo Cheng Yuan, Francesco Sorrentino, Edward Ott

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Epigenetic modifications to histones may promote either activation or repression of the transcription of nearby genes. Recent experimental studies show that the promoters of many lineage-control genes in stem cells have "bivalent domains" in which the nucleosomes contain both active (H3K4me3) and repressive (H3K27me3) marks. It is generally agreed that bivalent domains play an important role in stem cell differentiation, but the underlying mechanisms remain unclear. Here we formulate a mathematical model to investigate the dynamic properties of histone modification patterns. We then illustrate that our modeling framework can be used to capture key features of experimentally observed combinatorial chromatin states. Copyright:

Original language	English
Article number	e77944
Journal	PLoS ONE
Volume	8
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0077944
State	Published - Nov 2013
Externally published	Yes

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Modeling the dynamics of bivalent histone modifications

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