Modeling the circadian substructure: Coupled oscillators and entrainment

S. Yang; S. S. Reisman; W. N. Tapp; B. H. Natelson

doi:10.1109/iembs.1988.95066

Modeling the circadian substructure: Coupled oscillators and entrainment

S. Yang, S. S. Reisman, W. N. Tapp, B. H. Natelson

Research output: Contribution to conference › Paper › peer-review

1 Scopus citations

Abstract

Many circadian rhythms exhibit two peaks, but most mathematical models of circadian rhythms have not examined this issue. The authors simulated the bimodal circadian substructure with a system of two coupled oscillators where one oscillator's natural frequency was in the circadian range (20-30 hr.) and the second oscillator's period was roughly half of the circadian period (e.g., 12.5 hr). The circadian part of this system could be entrained by external stimuli, but the high-frequency second oscillator was only weakly affected by entraining stimuli. Important features of actual data that were simulated by this system were bimodal peaks, with the secondary peak moving progressively through the main peak, and low-frequency fluctuations, below the frequency of either oscillator.

Original language	English
Pages	1822-1823
Number of pages	2
DOIs	https://doi.org/10.1109/iembs.1988.95066
State	Published - 1988
Externally published	Yes
Event	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society - New Orleans, LA, USA Duration: 4 Nov 1988 → 7 Nov 1988

Conference

Conference	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society
City	New Orleans, LA, USA
Period	4/11/88 → 7/11/88

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10.1109/iembs.1988.95066

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title = "Modeling the circadian substructure: Coupled oscillators and entrainment",

abstract = "Many circadian rhythms exhibit two peaks, but most mathematical models of circadian rhythms have not examined this issue. The authors simulated the bimodal circadian substructure with a system of two coupled oscillators where one oscillator's natural frequency was in the circadian range (20-30 hr.) and the second oscillator's period was roughly half of the circadian period (e.g., 12.5 hr). The circadian part of this system could be entrained by external stimuli, but the high-frequency second oscillator was only weakly affected by entraining stimuli. Important features of actual data that were simulated by this system were bimodal peaks, with the secondary peak moving progressively through the main peak, and low-frequency fluctuations, below the frequency of either oscillator.",

author = "S. Yang and Reisman, {S. S.} and Tapp, {W. N.} and Natelson, {B. H.}",

year = "1988",

doi = "10.1109/iembs.1988.95066",

language = "English",

pages = "1822--1823",

note = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society ; Conference date: 04-11-1988 Through 07-11-1988",

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T1 - Modeling the circadian substructure

T2 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society

AU - Yang, S.

AU - Reisman, S. S.

AU - Tapp, W. N.

AU - Natelson, B. H.

PY - 1988

Y1 - 1988

N2 - Many circadian rhythms exhibit two peaks, but most mathematical models of circadian rhythms have not examined this issue. The authors simulated the bimodal circadian substructure with a system of two coupled oscillators where one oscillator's natural frequency was in the circadian range (20-30 hr.) and the second oscillator's period was roughly half of the circadian period (e.g., 12.5 hr). The circadian part of this system could be entrained by external stimuli, but the high-frequency second oscillator was only weakly affected by entraining stimuli. Important features of actual data that were simulated by this system were bimodal peaks, with the secondary peak moving progressively through the main peak, and low-frequency fluctuations, below the frequency of either oscillator.

AB - Many circadian rhythms exhibit two peaks, but most mathematical models of circadian rhythms have not examined this issue. The authors simulated the bimodal circadian substructure with a system of two coupled oscillators where one oscillator's natural frequency was in the circadian range (20-30 hr.) and the second oscillator's period was roughly half of the circadian period (e.g., 12.5 hr). The circadian part of this system could be entrained by external stimuli, but the high-frequency second oscillator was only weakly affected by entraining stimuli. Important features of actual data that were simulated by this system were bimodal peaks, with the secondary peak moving progressively through the main peak, and low-frequency fluctuations, below the frequency of either oscillator.

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DO - 10.1109/iembs.1988.95066

M3 - Paper

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SP - 1822

EP - 1823

Y2 - 4 November 1988 through 7 November 1988

ER -

Modeling the circadian substructure: Coupled oscillators and entrainment

Abstract

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