TY - GEN
T1 - Modeling of change in blood volume and extracellular fluid volume during hemodialysis
AU - Zhu, Fansan
AU - Kappel, Franz
AU - Leonard, Edward F.
AU - Kotanko, Peter
AU - Levin, Nathan W.
PY - 2013
Y1 - 2013
N2 - Knowledge of dynamics of shift of fluid volume between intra- and extravascular compartments during hemodialysis (HD) is important for managing HD treatment to help patients approach dry weight without hypotension. The Relative blood volume (RBV) monitor indicates change in plasma volume based on the difference between ultrafiltration rate (UFR) and plasma refilling rate (PRR) during HD. However, the absolute value of PRR cannot be obtained from RBV. The aim of this study was to investigate whether fluid transport from the interstitial to blood spaces can be quantitatively analyzed with a two compartments model. 14 patients (30 measurements) were studied. RBV using a blood volume monitor (BVM, Fresenius) and calf extracellular volumes (ECV) by calf bioimpedance device (Hydra 4200, Xitron) were continuously measured during HD. A mathematic model was established with unknown transport coefficients (k1, k2, α, β, γ, δ) and these coefficients were estimated using a Least Squares Optimization algorithm by fitting from experimental data. A high correlation (R2>0.8) between experimental data and calculation by the model were observed in both RBV and ECV measurements. Coefficients k1 and δ significantly differed with different degree of hydration. This model provides parameters which can used to understand relationships between degree of hydration and refilling rate.
AB - Knowledge of dynamics of shift of fluid volume between intra- and extravascular compartments during hemodialysis (HD) is important for managing HD treatment to help patients approach dry weight without hypotension. The Relative blood volume (RBV) monitor indicates change in plasma volume based on the difference between ultrafiltration rate (UFR) and plasma refilling rate (PRR) during HD. However, the absolute value of PRR cannot be obtained from RBV. The aim of this study was to investigate whether fluid transport from the interstitial to blood spaces can be quantitatively analyzed with a two compartments model. 14 patients (30 measurements) were studied. RBV using a blood volume monitor (BVM, Fresenius) and calf extracellular volumes (ECV) by calf bioimpedance device (Hydra 4200, Xitron) were continuously measured during HD. A mathematic model was established with unknown transport coefficients (k1, k2, α, β, γ, δ) and these coefficients were estimated using a Least Squares Optimization algorithm by fitting from experimental data. A high correlation (R2>0.8) between experimental data and calculation by the model were observed in both RBV and ECV measurements. Coefficients k1 and δ significantly differed with different degree of hydration. This model provides parameters which can used to understand relationships between degree of hydration and refilling rate.
UR - https://www.scopus.com/pages/publications/84886507846
U2 - 10.1109/EMBC.2013.6609798
DO - 10.1109/EMBC.2013.6609798
M3 - Conference contribution
C2 - 24109985
AN - SCOPUS:84886507846
SN - 9781457702167
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1506
EP - 1509
BT - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
T2 - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Y2 - 3 July 2013 through 7 July 2013
ER -