TY - JOUR
T1 - Modeling leukemia with human induced pluripotent stem cells
AU - Papapetrou, Eirini P.
N1 - Publisher Copyright:
© 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2019/12
Y1 - 2019/12
N2 - The reprogramming of human somatic cells into induced pluripotent stem cells (iPSCs) a little over a decade ago raised exciting prospects to transform the study and potentially also the therapy of human diseases. iPSC models have now been created for a multitude of hematologic diseases, including malignancies. Here we discuss practical aspects of iPSC modeling of malignant diseases, review recent studies, and discuss the new opportunities that iPSC models offer, as well as their current limitations and prospects for future development.
AB - The reprogramming of human somatic cells into induced pluripotent stem cells (iPSCs) a little over a decade ago raised exciting prospects to transform the study and potentially also the therapy of human diseases. iPSC models have now been created for a multitude of hematologic diseases, including malignancies. Here we discuss practical aspects of iPSC modeling of malignant diseases, review recent studies, and discuss the new opportunities that iPSC models offer, as well as their current limitations and prospects for future development.
UR - https://www.scopus.com/pages/publications/85076065443
U2 - 10.1101/cshperspect.a034868
DO - 10.1101/cshperspect.a034868
M3 - Article
C2 - 31451537
AN - SCOPUS:85076065443
SN - 2157-1422
VL - 9
JO - Cold Spring Harbor Perspectives in Medicine
JF - Cold Spring Harbor Perspectives in Medicine
IS - 12
M1 - a034868
ER -