Abstract

The reprogramming of human somatic cells into induced pluripotent stem cells (iPSCs) a little over a decade ago raised exciting prospects to transform the study and potentially also the therapy of human diseases. iPSC models have now been created for a multitude of hematologic diseases, including malignancies. Here we discuss practical aspects of iPSC modeling of malignant diseases, review recent studies, and discuss the new opportunities that iPSC models offer, as well as their current limitations and prospects for future development.

Original languageEnglish
Article numbera034868
JournalCold Spring Harbor Perspectives in Medicine
Volume9
Issue number12
DOIs
StatePublished - Dec 2019

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