Abstract

Patient-derived induced pluripotent stem cells (iPSCs) have recently provided a new way to model acute myeloid leukemia (AML) and other myeloid malignancies. Here, we describe methods for the generation of patient-derived iPSCs from leukemia cells and for their subsequent directed in vitro differentiation into hematopoietic cells that recapitulate features of leukemia stem cells (LSCs) and leukemic blasts.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages411-422
Number of pages12
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2185
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • AML
  • Human induced pluripotent stem cells
  • Reprogramming
  • hPSC-hematopoiesis
  • iPSC disease modeling

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