Modeling Cancer with Pluripotent Stem Cells

Julian Gingold, Ruoji Zhou, Ihor R. Lemischka, Dung Fang Lee

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

The elucidation of cancer pathogenesis has been hindered by limited access to patient samples, tumor heterogeneity, and the lack of reliable model organisms. Characterized by their ability to self-renew indefinitely and differentiate into all adult cell lineages of an organism, pluripotent stem cells (PSCs), including ESCs and induced pluripotent stem cells (iPSCs), provide a powerful and unlimited source to generate differentiated cells that can be used to study disease biology, facilitate drug discovery and development, and provide key insights for developing personalized therapies. This article reviews the recent developments and technologies converting PSCs into clinically relevant model systems for cancer research.

Original languageEnglish
Pages (from-to)485-494
Number of pages10
JournalTrends in Cancer
Volume2
Issue number9
DOIs
StatePublished - 1 Sep 2016

Keywords

  • cancer disease modeling
  • differentiation
  • genome editing
  • pluripotent stem cells

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