Modeling-Based Response-Guided Hepatitis C Treatment during Pregnancy and Postpartum

Tatyana Kushner; Custon T. Nyabanga; Scott J. Cotler; Ohad Etzion; Harel Dahari

doi:10.1093/ofid/ofad027

Modeling-Based Response-Guided Hepatitis C Treatment during Pregnancy and Postpartum

Tatyana Kushner, Custon T. Nyabanga, Scott J. Cotler, Ohad Etzion, Harel Dahari

Research output: Contribution to journal › Article › peer-review

Abstract

Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery-16days post-initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5weeks.

Original language	English
Article number	ofad027
Journal	Open Forum Infectious Diseases
Volume	10
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofad027
State	Published - 1 Feb 2023

Keywords

antiviral therapy
hepatitis C virus
pregnancy
response-guided treatment

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10.1093/ofid/ofad027

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title = "Modeling-Based Response-Guided Hepatitis C Treatment during Pregnancy and Postpartum",

abstract = "Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery-16days post-initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5weeks.",

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AU - Kushner, Tatyana

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AU - Etzion, Ohad

AU - Dahari, Harel

PY - 2023/2/1

Y1 - 2023/2/1

N2 - Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery-16days post-initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5weeks.

AB - Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery-16days post-initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5weeks.

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Modeling-Based Response-Guided Hepatitis C Treatment during Pregnancy and Postpartum

Abstract

Keywords

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