Model peptides and cholesterol

István P. Sugár, Parkson Lee Gau Chong

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Proteins and lipids are the two major components of cell membranes. From the many membrane proteins and lipids, here we select one peptide (gramicidin) and two typical lipids (dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and cholesterol) and develop a statistical mechanical model of this three-component membrane. This model is a combination of two of our previously developed membrane models: DMPC/cholesterol and DMPC/gramicidin. Using our model, the proportion of the densely packed area (i.e., the area covered by the rigid clusters) can be calculated if the compositions of the two layers of the membrane are the same. The results of our model can be experimentally tested by measuring the proportion of the densely packed area.

Original languageEnglish
Title of host publicationCholesterol
Subtitle of host publicationFrom Chemistry and Biophysics to the Clinic
Number of pages12
ISBN (Electronic)9780323858571
ISBN (Print)9780323858588
StatePublished - 1 Jan 2022


  • Cholesterol
  • Condensed complex
  • Gramicidin
  • Lateral organization
  • Model peptides
  • Regular distribution
  • Statistical mechanical lipid membrane model
  • Superlattices


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