Mobilized Hematopoietic Stem Cell Yield Depends on Species-Specific Circadian Timing

Daniel Lucas, Michela Battista, Patricia A. Shi, Luis Isola, Paul S. Frenette

Research output: Contribution to journalLetterpeer-review

190 Scopus citations


Endogenous rhythmicity likely evolved as a mechanism allowing organisms to anticipate predictable daily changes in the environment (Rutter et al., 2002). Under homeostasis, murine hematopoietic stem cell (HSC) egress is orchestrated by rhythmic β3 adrenergic signals delivered by the sympathetic nervous system (SNS) that regulate Cxcl12 expression in stromal cells (Mendez-Ferrer et al., 2008). Here, we show that CXCR4 is also regulated under circadian control whose rhythm is synchronized with its ligand, CXCL12, to optimize HSC trafficking. These circadian oscillations are inverted in humans compared to the mouse and continue to influence the yield even when stem cell mobilization is enforced. Our results suggest that the human HSC yield for clinical transplantation might be significantly greater if patients were harvested during the evening compared to the morning.

Original languageEnglish
Pages (from-to)364-366
Number of pages3
JournalCell Stem Cell
Issue number4
StatePublished - 9 Oct 2008


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