MMTV-like env gene sequences in human breast cancer

Y. Wang; I. Pelisson; S. M. Melana; V. Go; J. F. Holland; B. G.T. Pogo

doi:10.1007/s007050170201

MMTV-like env gene sequences in human breast cancer

Y. Wang, I. Pelisson, S. M. Melana, V. Go, J. F. Holland, B. G.T. Pogo

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Abstract

We have previously detected an MMTV env gene-like 660 bp sequence in 38% of human breast cancers, but not in normal tissues or other tumors. In this communication we report the sequences from eleven tumors and three breast cancer cell lines, and compare them to four strains of MMTV and to the known endogenous retroviral sequences. The breast cancer sequences were highly homogenous to the MMTV's, but not to the endogenous sequences suggesting an exogenous origin.

Original language	English
Pages (from-to)	171-180
Number of pages	10
Journal	Archives of Virology
Volume	146
Issue number	1
DOIs	https://doi.org/10.1007/s007050170201
State	Published - 2001

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abstract = "We have previously detected an MMTV env gene-like 660 bp sequence in 38% of human breast cancers, but not in normal tissues or other tumors. In this communication we report the sequences from eleven tumors and three breast cancer cell lines, and compare them to four strains of MMTV and to the known endogenous retroviral sequences. The breast cancer sequences were highly homogenous to the MMTV's, but not to the endogenous sequences suggesting an exogenous origin.",

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AU - Go, V.

AU - Holland, J. F.

AU - Pogo, B. G.T.

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AB - We have previously detected an MMTV env gene-like 660 bp sequence in 38% of human breast cancers, but not in normal tissues or other tumors. In this communication we report the sequences from eleven tumors and three breast cancer cell lines, and compare them to four strains of MMTV and to the known endogenous retroviral sequences. The breast cancer sequences were highly homogenous to the MMTV's, but not to the endogenous sequences suggesting an exogenous origin.

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MMTV-like env gene sequences in human breast cancer

Abstract

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