Mixed agglutination between established burkitt cell lines and fresh biopsy specimens [25]

Richard T. Smith; George Klein; Eva Klein; Peter Clifford

doi:10.1038/216693a0

Mixed agglutination between established burkitt cell lines and fresh biopsy specimens [25]

Richard T. Smith, George Klein, Eva Klein, Peter Clifford

Research output: Contribution to journal › Letter › peer-review

Abstract

WHEN the serum from patients with Burkitt-type lymphoma is incubated with living suspensions consisting mostly of Burkitt tumour cells, the cell surfaces become coated with immunoglobulin as detected by the fluorescent antibody technique¹. Evidence suggests that this surface reaction is correlated with the occurrence of a virus like particle, and that this particle is also associated with a cytoplasmic antigen detected by the fluorescent antibody technique², but there are good reasons to distinguish between this and the membrane fluorescence phenomenon demonstrable on the living cell.

Original language	English
Pages (from-to)	693-694
Number of pages	2
Journal	Nature
Volume	216
Issue number	5116
DOIs	https://doi.org/10.1038/216693a0
State	Published - 1967
Externally published	Yes

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title = "Mixed agglutination between established burkitt cell lines and fresh biopsy specimens [25]",

abstract = "WHEN the serum from patients with Burkitt-type lymphoma is incubated with living suspensions consisting mostly of Burkitt tumour cells, the cell surfaces become coated with immunoglobulin as detected by the fluorescent antibody technique1. Evidence suggests that this surface reaction is correlated with the occurrence of a virus like particle, and that this particle is also associated with a cytoplasmic antigen detected by the fluorescent antibody technique2, but there are good reasons to distinguish between this and the membrane fluorescence phenomenon demonstrable on the living cell.",

author = "Smith, {Richard T.} and George Klein and Eva Klein and Peter Clifford",

year = "1967",

doi = "10.1038/216693a0",

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journal = "Nature",

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T1 - Mixed agglutination between established burkitt cell lines and fresh biopsy specimens [25]

AU - Smith, Richard T.

AU - Klein, George

AU - Klein, Eva

AU - Clifford, Peter

PY - 1967

Y1 - 1967

N2 - WHEN the serum from patients with Burkitt-type lymphoma is incubated with living suspensions consisting mostly of Burkitt tumour cells, the cell surfaces become coated with immunoglobulin as detected by the fluorescent antibody technique1. Evidence suggests that this surface reaction is correlated with the occurrence of a virus like particle, and that this particle is also associated with a cytoplasmic antigen detected by the fluorescent antibody technique2, but there are good reasons to distinguish between this and the membrane fluorescence phenomenon demonstrable on the living cell.

AB - WHEN the serum from patients with Burkitt-type lymphoma is incubated with living suspensions consisting mostly of Burkitt tumour cells, the cell surfaces become coated with immunoglobulin as detected by the fluorescent antibody technique1. Evidence suggests that this surface reaction is correlated with the occurrence of a virus like particle, and that this particle is also associated with a cytoplasmic antigen detected by the fluorescent antibody technique2, but there are good reasons to distinguish between this and the membrane fluorescence phenomenon demonstrable on the living cell.

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U2 - 10.1038/216693a0

DO - 10.1038/216693a0

M3 - Letter

C2 - 4170400

AN - SCOPUS:0014210557

SN - 0028-0836

VL - 216

SP - 693

EP - 694

JO - Nature

JF - Nature

IS - 5116

ER -

Mixed agglutination between established burkitt cell lines and fresh biopsy specimens [25]

Abstract

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