Mitophagy and aging

The cellular constituents are transported into lysosomes for breakdown and recycling via the primary protein turnover mechanism known as mitophagy. Under stressful circumstances, this intracellular process can preserve cellular homeostasis, and its dysregulation may result in physiological changes. Age-related declines in autophagic activity are considered to be a factor in the buildup of harmed macromolecules and organelles. Interestingly, the failure of these mitophagy pathways has also been linked to worsening age-related ailments, including cancer and neurological problems. Similarly, it has been suggested that maintaining adequate mitophagy functions extends longevity in other creatures. In this review, we address current studies that demonstrate the molecular, signaling, and mitochondrial bases of aging. The chapter also covered the effects of mitophagy on many organs and disorders linked to aging, emphasizing how pertinent this process is to the symptoms of aging. Understanding how autophagy affects aging thus opens up new opportunities for identifying biochemical and pharmacological targets, i.e., synthetic and natural compounds to modulate mitophagy during aging and the creation of cutting-edge anti-aging therapeutic strategies.