Mitogen-Activated protein kinase signaling mediates phosphorylation of polycomb ortholog cbx7

Hsan Au Wu; Jeremy L. Balsbaugh; Hollie Chandler; Athena Georgilis; Hayley Zullow; Jeffrey Shabanowitz; Jesus Gil; Gordon Peters; Emily Bernstein

doi:10.1074/jbc.M113.486266

Mitogen-Activated protein kinase signaling mediates phosphorylation of polycomb ortholog cbx7

Hsan Au Wu
, Jeremy L. Balsbaugh
, Hollie Chandler
, Athena Georgilis
, Hayley Zullow
, Jeffrey Shabanowitz
, Jesus Gil
, Gordon Peters
, Emily Bernstein

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Post-translational modification of Polycomb protein Cbx7 remains poorly understood. Results: Here we identify and characterize a novel phosphorylation site at threonine 118 of mouse Cbx7. Conclusion: MAPK signaling induces Cbx7 threonine 118 phosphorylation and enhances PRC1 association. Significance: Mitogen signaling to Cbx7 confers an additional layer of PRC1 regulation.

Original language	English
Pages (from-to)	36398-36408
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	51
DOIs	https://doi.org/10.1074/jbc.M113.486266
State	Published - 20 Dec 2013

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10.1074/jbc.M113.486266

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title = "Mitogen-Activated protein kinase signaling mediates phosphorylation of polycomb ortholog cbx7",

abstract = "Background: Post-translational modification of Polycomb protein Cbx7 remains poorly understood. Results: Here we identify and characterize a novel phosphorylation site at threonine 118 of mouse Cbx7. Conclusion: MAPK signaling induces Cbx7 threonine 118 phosphorylation and enhances PRC1 association. Significance: Mitogen signaling to Cbx7 confers an additional layer of PRC1 regulation.",

author = "Wu, \{Hsan Au\} and Balsbaugh, \{Jeremy L.\} and Hollie Chandler and Athena Georgilis and Hayley Zullow and Jeffrey Shabanowitz and Jesus Gil and Gordon Peters and Emily Bernstein",

year = "2013",

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doi = "10.1074/jbc.M113.486266",

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T1 - Mitogen-Activated protein kinase signaling mediates phosphorylation of polycomb ortholog cbx7

AU - Wu, Hsan Au

AU - Balsbaugh, Jeremy L.

AU - Chandler, Hollie

AU - Georgilis, Athena

AU - Zullow, Hayley

AU - Shabanowitz, Jeffrey

AU - Gil, Jesus

AU - Peters, Gordon

AU - Bernstein, Emily

PY - 2013/12/20

Y1 - 2013/12/20

N2 - Background: Post-translational modification of Polycomb protein Cbx7 remains poorly understood. Results: Here we identify and characterize a novel phosphorylation site at threonine 118 of mouse Cbx7. Conclusion: MAPK signaling induces Cbx7 threonine 118 phosphorylation and enhances PRC1 association. Significance: Mitogen signaling to Cbx7 confers an additional layer of PRC1 regulation.

AB - Background: Post-translational modification of Polycomb protein Cbx7 remains poorly understood. Results: Here we identify and characterize a novel phosphorylation site at threonine 118 of mouse Cbx7. Conclusion: MAPK signaling induces Cbx7 threonine 118 phosphorylation and enhances PRC1 association. Significance: Mitogen signaling to Cbx7 confers an additional layer of PRC1 regulation.

UR - https://www.scopus.com/pages/publications/84890923288

U2 - 10.1074/jbc.M113.486266

DO - 10.1074/jbc.M113.486266

M3 - Article

C2 - 24194518

AN - SCOPUS:84890923288

SN - 0021-9258

VL - 288

SP - 36398

EP - 36408

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 51

ER -

Mitogen-Activated protein kinase signaling mediates phosphorylation of polycomb ortholog cbx7

Abstract

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