Mitochondrial regulation of hematopoietic stem cells

Hans Willem Snoeck

doi:10.1016/j.ceb.2017.12.010

Mitochondrial regulation of hematopoietic stem cells

Hans Willem Snoeck

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Hematopoietic stem cells (HSCs) preferentially use glycolysis rather than mitochondrial oxidative phosphorylation for energy production. While glycolysis in HSC is typically viewed as response to a hypoxic bone marrow environment that protects HSC from damaging reactive oxygen species, other interpretations are possible. Furthermore, recent evidence directly supports a critical role for mitochondria in the maintenance and function of HSCs that goes beyond ATP production. Here, we review recent advances in our understanding of metabolism and the role of mitochondria in the biology of HSCs.

Original language	English
Pages (from-to)	91-98
Number of pages	8
Journal	Current Opinion in Cell Biology
Volume	49
DOIs	https://doi.org/10.1016/j.ceb.2017.12.010
State	Published - Dec 2017
Externally published	Yes

Access to Document

10.1016/j.ceb.2017.12.010

Cite this

@article{d4498756d19341dca1960cf1a1b1a2a1,

title = "Mitochondrial regulation of hematopoietic stem cells",

abstract = "Hematopoietic stem cells (HSCs) preferentially use glycolysis rather than mitochondrial oxidative phosphorylation for energy production. While glycolysis in HSC is typically viewed as response to a hypoxic bone marrow environment that protects HSC from damaging reactive oxygen species, other interpretations are possible. Furthermore, recent evidence directly supports a critical role for mitochondria in the maintenance and function of HSCs that goes beyond ATP production. Here, we review recent advances in our understanding of metabolism and the role of mitochondria in the biology of HSCs.",

author = "Snoeck, {Hans Willem}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

month = dec,

doi = "10.1016/j.ceb.2017.12.010",

language = "English",

volume = "49",

pages = "91--98",

journal = "Current Opinion in Cell Biology",

issn = "0955-0674",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Mitochondrial regulation of hematopoietic stem cells

AU - Snoeck, Hans Willem

PY - 2017/12

Y1 - 2017/12

N2 - Hematopoietic stem cells (HSCs) preferentially use glycolysis rather than mitochondrial oxidative phosphorylation for energy production. While glycolysis in HSC is typically viewed as response to a hypoxic bone marrow environment that protects HSC from damaging reactive oxygen species, other interpretations are possible. Furthermore, recent evidence directly supports a critical role for mitochondria in the maintenance and function of HSCs that goes beyond ATP production. Here, we review recent advances in our understanding of metabolism and the role of mitochondria in the biology of HSCs.

AB - Hematopoietic stem cells (HSCs) preferentially use glycolysis rather than mitochondrial oxidative phosphorylation for energy production. While glycolysis in HSC is typically viewed as response to a hypoxic bone marrow environment that protects HSC from damaging reactive oxygen species, other interpretations are possible. Furthermore, recent evidence directly supports a critical role for mitochondria in the maintenance and function of HSCs that goes beyond ATP production. Here, we review recent advances in our understanding of metabolism and the role of mitochondria in the biology of HSCs.

UR - http://www.scopus.com/inward/record.url?scp=85040016047&partnerID=8YFLogxK

U2 - 10.1016/j.ceb.2017.12.010

DO - 10.1016/j.ceb.2017.12.010

M3 - Review article

C2 - 29309987

AN - SCOPUS:85040016047

SN - 0955-0674

VL - 49

SP - 91

EP - 98

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

ER -

Mitochondrial regulation of hematopoietic stem cells

Abstract

Access to Document

Fingerprint

Cite this