Mitochondrial outer membrane permeabilization during apoptosis: The innocent bystander scenario

J. E. Chipuk, L. Bouchier-Hayes, Douglas R. Green

Research output: Contribution to journalReview articlepeer-review

481 Scopus citations

Abstract

Mitochondrial outer membrane permeabilization (MOMP) is considered the 'point of no return' as this event is responsible for engaging the apoptotic cascade in numerous cell death pathways. MOMP is directly governed by a subset of the BCL-2 family of proapoptotic proteins, which induce disruptions in the outer mitochondrial membrane (OMM) and subsequent release of death-promoting proteins like cytochrome c. The proposal here is centered on our hypothesis that MOMP is dictated by an interaction between the cytosol and the OMM, and although proteins of the OMM may be important in the process, the 'decision' to undergo apoptosis originates within the cytosol with no participation (in terms of yes, no and when) by mitochondria.

Original languageEnglish
Pages (from-to)1396-1402
Number of pages7
JournalCell Death and Differentiation
Volume13
Issue number8
DOIs
StatePublished - Aug 2006
Externally publishedYes

Keywords

  • Apoptosis
  • BCL-2 proteins
  • BH3-only proteins
  • MOMP
  • Membrane
  • Mitochondria

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