Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination

Raymond Liang, Saghi Ghaffari

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The production of all blood cells from hematopoietic stem cells (HSC) is highly sensitive to reactive oxygen species (ROS). Cumulating evidence suggests that mitochondria are critical for HSC fate determination. FOXO are known regulators of anti-oxidant response and key to the maintenance of HSC. Recent works indicate that FOXO3 is implicated in the control of mitochondrial function beyond regulating levels of ROS in HSC. Here we review these findings and discuss implications for homeostatic blood formation and stem cell fate determination.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalJournal of Bioenergetics and Biomembranes
Volume49
Issue number4
DOIs
StatePublished - 1 Aug 2017

Keywords

  • FOXO
  • FOXO3
  • HSC
  • Mitochondria
  • ROS
  • Stem cell
  • UPR

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