Mitochondria and Alzheimer's: Is PTCD1 the Smoking Gun?

Judy Pa; Shea J. Andrews; Russell H. Swerdlow

doi:10.1016/j.tins.2019.08.003

Mitochondria and Alzheimer's: Is PTCD1 the Smoking Gun?

Judy Pa
, Shea J. Andrews
, Russell H. Swerdlow

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

Multiple features distinguish the mitochondria of Alzheimer's disease (AD) patients from those of unaffected individuals. The causes and consequences of these differences are informed by the recent finding by Fleck et al. (J. Neurosci., 2019) that pentatricopeptide repeat-containing protein 1 (PTCD1) gene variants associate with AD. This suggests a proximal or initiating role for mitochondria in AD.

Original language	English
Pages (from-to)	759-762
Number of pages	4
Journal	Trends in Neurosciences
Volume	42
Issue number	11
DOIs	https://doi.org/10.1016/j.tins.2019.08.003
State	Published - Nov 2019

Keywords

Alzheimer's disease
PTCD1
mitochondria

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10.1016/j.tins.2019.08.003

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title = "Mitochondria and Alzheimer's: Is PTCD1 the Smoking Gun?",

abstract = "Multiple features distinguish the mitochondria of Alzheimer's disease (AD) patients from those of unaffected individuals. The causes and consequences of these differences are informed by the recent finding by Fleck et al. (J. Neurosci., 2019) that pentatricopeptide repeat-containing protein 1 (PTCD1) gene variants associate with AD. This suggests a proximal or initiating role for mitochondria in AD.",

keywords = "Alzheimer's disease, PTCD1, mitochondria",

author = "Judy Pa and Andrews, \{Shea J.\} and Swerdlow, \{Russell H.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = nov,

doi = "10.1016/j.tins.2019.08.003",

language = "English",

volume = "42",

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T2 - Is PTCD1 the Smoking Gun?

AU - Pa, Judy

AU - Andrews, Shea J.

AU - Swerdlow, Russell H.

PY - 2019/11

Y1 - 2019/11

N2 - Multiple features distinguish the mitochondria of Alzheimer's disease (AD) patients from those of unaffected individuals. The causes and consequences of these differences are informed by the recent finding by Fleck et al. (J. Neurosci., 2019) that pentatricopeptide repeat-containing protein 1 (PTCD1) gene variants associate with AD. This suggests a proximal or initiating role for mitochondria in AD.

AB - Multiple features distinguish the mitochondria of Alzheimer's disease (AD) patients from those of unaffected individuals. The causes and consequences of these differences are informed by the recent finding by Fleck et al. (J. Neurosci., 2019) that pentatricopeptide repeat-containing protein 1 (PTCD1) gene variants associate with AD. This suggests a proximal or initiating role for mitochondria in AD.

KW - Alzheimer's disease

KW - PTCD1

KW - mitochondria

UR - https://www.scopus.com/pages/publications/85070540213

U2 - 10.1016/j.tins.2019.08.003

DO - 10.1016/j.tins.2019.08.003

M3 - Short survey

C2 - 31421943

AN - SCOPUS:85070540213

SN - 0166-2236

VL - 42

SP - 759

EP - 762

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 11

ER -

Mitochondria and Alzheimer's: Is PTCD1 the Smoking Gun?

Abstract

Keywords

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